Annexin 2 Antibody (YA2711)

Annexin 2 Antibody (YA2711) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2711), targeting Annexin 2, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). Annexin 2 Antibody (YA2711) can be used for WB, IP experiment in human background.

Annexin A2 is a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity and may be involved in heat-stress response. The protein inhibits PCSK9-enhanced LDLR degradation, likely by reducing PCSK9 protein levels via a translational mechanism while also competing with LDLR for PCSK9 binding. Annexin A2 binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (by similarity). It is required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (by similarity). In microbial infection, Annexin A2 binds M. pneumoniae CARDS toxin, probably serving as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells, and vacuolization (a symptom of M. pneumoniae infection) is reduced.

P07355

Predicted band size: 39 kDa; Observed band size: 39 kDa

Affinity Purified

Non-conjugated

Unmodified

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000;IP: 1/20

WB, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein of human Annexin-2/ANXA2