CRCP Antibody (YA3350)

Cat. No.: HY-P83605: Data Sheet COA
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CRCP Antibody (YA3350) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3350), targeting CRCP, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). CRCP Antibody (YA3350) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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CRCP Antibody (YA3350) Featured Recommendations:

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

Biological Activity
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Description	CRCP Antibody (YA3350) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3350), targeting CRCP, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). CRCP Antibody (YA3350) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.
Background	CRCP is a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is a specific peripheral component of RNA polymerase III (Pol III), which synthesizes small non-coding RNAs, including 5S rRNA, snRNAs, tRNAs, and miRNAs, from at least 500 distinct genomic loci. Together with POLR3H/RPC8, it forms a mobile stalk that protrudes from the Pol III core and primarily functions in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, acting as a nuclear and cytosolic DNA sensor involved in the innate immune response. It can sense non-self dsDNA, which serves as a template for transcription into dsRNA. Non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-kappa-B through the RIG-I pathway. Additionally, CRCP serves as an accessory protein for the calcitonin gene-related peptide (CGRP) receptor, modulating CGRP responsiveness in various tissues.
Gene ID	27297 [NCBI]
SwissProt ID	O75575
Synonyms	C17; RCP; RCP9; RPC9; POLR3I; POLR3J; CGRPRCP; CGRP-RCP
Molecular Weight	Predicted band size: 17 kDa; Observed band size: 17 kDa
Purity	Affinity Purified
Conjugation	Non-conjugated
Modification	Unmodified
RRID	AB_3105713
Research Field	Neuroscience
Product Categories	Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality	Recombinant, Monoclonal
Host	Rabbit
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;IP: 1/20
Application	WB, IHC-F, IHC-P, ICC/IF, IP
Appearance	Liquid
Formulation	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG
Sensitivity	Endogenous
Immunogen	A synthetic peptide of human CRCP
Database	Entrez Gene: 27297 Human ; 12909 Mouse ; 114205 Rat SwissProt: O75575 Human ; O35427 Mouse ; Q8VHM6 Rat OMIM: 606121 Human
Documentation	Select Batch: Data Sheet (235 KB) SDS (251 KB) COA (191 KB) User Guide for Antibodies (1077 KB)

CRCP Antibody (YA3350) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CRCP Antibody (YA3350)

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