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Results for "

Na<sup> </sup>/K<sup> </sup> ATPase

" in MedChemExpress (MCE) Product Catalog:

4531

Inhibitors & Agonists

26

Screening Libraries

36

Fluorescent Dye

58

Biochemical Assay Reagents

228

Peptides

4

MCE Kits

34

Inhibitory Antibodies

516

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Products

399

Recombinant Proteins

1358

Isotope-Labeled Compounds

298

Antibodies

15

Click Chemistry

175

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15306S
    Eltrombopag-13C4
    1 Publications Verification

    SB-497115-<sup>13sup>C4

    		 Thrombopoietin Receptor Bacterial Apoptosis Infection Cardiovascular Disease Cancer
    Eltrombopag- 13C4 (SB-497115- 13C4) is 13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .
    Eltrombopag-13C4
  • HY-126906
    Milbemycin A4

    		Antibiotic P-glycoprotein Cancer
    Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity [1]sup>[2].
    Milbemycin A4
  • HY-W011509
    CyPPA

    		Potassium Channel Neurological Disease
    CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels [1]sup .
    CyPPA
  • HY-N1446S
    Oleic acid-13C

    9-cis-Octadecenoic acid-<sup>13sup>C; 9Z-Octadecenoic acid-<sup>13sup>C

    		 Na+/K+ ATPase Endogenous Metabolite Apoptosis Metabolic Disease Cancer
    Oleic acid- 13C is the 13C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .
    Oleic acid-13C
  • HY-N12231
    Carbazomycin B

    		Antibiotic Bacterial Lipoxygenase Infection Cancer
    Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 µM [1]sup>[2]sup>[3]sup>[4].
    Carbazomycin B
  • HY-B0141S7
    rel-Estradiol-13C6

    		Isotope-Labeled Compounds Others
    rel-Estradiol- 13C6 is the sup>13C-labeled rel-Estradiol .
    rel-Estradiol-13C6
  • HY-157926
    Nitroso-PSAP

    		Biochemical Assay Reagents Others
    Nitroso-PSAP is a sensitive and specific chromogenic reagent for iron (Fe 2+), which is used for the colorimetric determination of iron in blood after mineralization with periodic acid. TNitroso-PSAP chelates with iron (Fe 2+) to produce a green complex (λmax=756 nm, Epsilon = 4.5 x 10 < sup > 4 < / sup > dm < sup > 3 < / sup > mol < sup > 1 < / sup > cm < sup > 1 < / sup >) .
    Nitroso-PSAP
  • HY-108166
    Hydroxystilbamidine

    		Fluorescent Dye Inflammation/Immunology
    Hydroxystilbamidine, a dye capable of binding to both DNA and RNA, is a powerful inhibitor of cellular ribonucleases. Hydroxystilbamidine is a retrograde fluorescent tracer and a histochemical stain [1]sup .
    Hydroxystilbamidine
  • HY-145128
    GR103545

    		Opioid Receptor Neurological Disease
    GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR). 11GR103545 is a radiotracer for imaging κ-OR in vivo [1]sup .
    GR103545
  • HY-N11122
    7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol

    		Others Others
    7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol is a cuminol glycoside. 7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol can be isolated from Rhodiola rosea sup>[1].
    7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol
  • HY-161119
    Drpitor1a

    		Dynamin Reactive Oxygen Species (ROS) Cardiovascular Disease Cancer
    Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer [1]sup .
    Drpitor1a
  • HY-126906R
    Milbemycin A4 (Standard)

    		Reference Standards Antibiotic P-glycoprotein Cancer
    Milbemycin A4 (Standard) is the analytical standard of Milbemycin A4. This product is intended for research and analytical applications. Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity [1]sup> .
    Milbemycin A4 (Standard)
  • HY-N1446S2
    Oleic acid-13C18

    9-cis-Octadecenoic acid-<sup>13sup>C18; 9Z-Octadecenoic acid-<sup>13sup>C18

    		 Na+/K+ ATPase Endogenous Metabolite Apoptosis Metabolic Disease Cancer
    Oleic acid- 13C18 is the 13C labeled Oleic acid (HY-N1446). Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .
    Oleic acid-13C18
  • HY-N7012
    7,3',4'-Tri-O-methylluteolin
    1 Publications Verification

    5-Hydroxy-3',4',7-trimethoxyflavone

    		 Lipoxygenase TNF Receptor Interleukin Related COX Fungal Parasite Apoptosis Infection Inflammation/Immunology Cancer
    7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid with multiple biological activities. 7,3',4'-Tri-O-methylluteolin inhibits soybean lipoxygenase (LOX), with an IC50 value of 23.97 µg/mL. 7,3',4'-Tri-O-methylluteolin possesses anti-inflammatory effects in Lipopolysaccharides (HY-D1056) (LPS)-induced RAW 264.7 macrophages. 7,3',4'-Tri-O-methylluteolin inhibits the binding of MDM2 with p53 and induces apoptosis in MCF-7 breast cancer cells. 7,3',4'-Tri-O-methylluteolin also has antioxidant, antifungal and antitrypanosomal activities [3]sup>[4]sup>[5].
    7,3',4'-Tri-O-methylluteolin
  • HY-12741
    LDN-212320
    5+ Cited Publications

    LDN-0212320; OSU-0212320

    		 EAAT Neurological Disease
    LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC [1]sup .
    LDN-212320
  • HY-N8824
    Maackiaflavanone

    		Others Others
    Maackiaflavanone (compound 4) is a kind of prenylated flavanone. Maackia can be isolated from M. amurensi.
    Maackiaflavanone
  • HY-Y0850U
    PVA (Mw 31000, 87-89% hydrolyzed, ~630 polymerization)

    Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ~630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ~630 polymerization)

    		 Biochemical Assay Reagents Others
    PVA (Mw 31000, 87-89% hydrolyzed, ~630 polymerization) (Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ~630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ~630 polymerization)) is a biocompatible, biodegradable, nontoxic and hydrophilic synthetic polymer. PVA (Mw 31000, 87-89% hydrolyzed, ~630 polymerization) can be used to produce bone tissue engineering scaffold [1]sup .
    PVA (Mw 31000, 87-89% hydrolyzed, ~630 polymerization)
  • HY-17405S
    Alarelin-(Leu-13C6,15N) TFA

    		Isotope-Labeled Compounds Others
    Alarelin-(Leu-sup>13C10, 15N) TFA is the 13C- and 15N-labeled Alarelin TFA.
    Alarelin-(Leu-13C6,15N) TFA
  • HY-P4583
    Suc-Val-Pro-Phe-SBzl

    		Cathepsin Others
    Suc-Val-Pro-Phe-SBzl (succinyl-valine-proline-phenylalanine thiobenzyl ester) is an inhibitor of CatG enzymes with IC50 values of 111-225 mM.
    Suc-Val-Pro-Phe-SBzl
  • HY-112499S1
    Menaquinone-7-13C6

    Vitamin K2-7-<sup>13sup>C6; Vitamin K2(35)-<sup>13sup>C6; Vitamin MK-7-<sup>13sup>C6

    		 Isotope-Labeled Compounds Cardiovascular Disease
    Menaquinone-7- 13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .
    Menaquinone-7-13C6
  • HY-N0684S3
    Vitamin K1-13C6

    Phylloquinone-<sup>13sup>C6; PhytomeNadione-<sup>13sup>C6

    		 Isotope-Labeled Compounds Endogenous Metabolite Cardiovascular Disease
    Vitamin K1- 13C6 is the 13C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
    Vitamin K1-13C6
  • HY-P6696S
    β-CL, Ala(13C3,15N) TFA

    		Isotope-Labeled Compounds Others
    β-CL, Ala(sup>13C3, 15N) TFA is the 13C- and 15N-labeled β-CL TFA.
    β-CL, Ala(13C3,15N) TFA
  • HY-W748319
    K 101-13C12

    CB 101-<sup>13sup>C12; PCB 101-<sup>13sup>C12; 2,2',4,5,5'-Pentachlorobiphenyl-<sup>13sup>C12

    		 Isotope-Labeled Compounds Others
    K 101- 13C12 is 13C labeled K 101 .
    K 101-13C12
  • HY-B0283S1
    Acipimox-13C2,15N2

    K-9321-<sup>13sup>C2,<sup>15sup>N2

    		 Isotope-Labeled Compounds Metabolic Disease
    Acipimox- 13C2, 15N2 (K-9321- 13C2, 15N2) is 13C- and 15N-labeled Acipimox (HY-B0283) .
    Acipimox-13C2,15N2
  • HY-14818S1
    Laninamivir-13C,15N2

    R 125489-<sup>13sup>C,<sup>15sup>N2

    		 Isotope-Labeled Compounds Influenza Virus Infection
    Laninamivir- 13C, 15N2 (R 125489- 13C, 15N2) is 13C and 15N labeled Laninamivir. Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively .
    Laninamivir-13C,15N2
  • HY-W008614S1
    Lansoprazole sulfone-13C6

    AG-1813-<sup>13sup>C6

    		 Isotope-Labeled Compounds Proton Pump Drug Metabolite Metabolic Disease
    Lansoprazole sulfone- 13C6 (AG-1813- 13C6) is 13C labeled Lansoprazole sulfone. Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H +, K +-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H +, K +-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .
    Lansoprazole sulfone-13C6
  • HY-N3872
    Ethyl β-D-glucopyranoside

    		Others Others
    Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.
    Ethyl β-D-glucopyranoside
  • HY-B0495S8
    Lamotrigine-13C7,15N

    LTG-<sup>13sup>C7,<sup>15sup>N; BW430C-<sup>13sup>C7,<sup>15sup>N

    		 Isotope-Labeled Compounds Autophagy Sodium Channel Neurological Disease Cancer
    Lamotrigine- 13C7, 15N (LTG- 13C7, 15N) is 13C and 15N labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .
    Lamotrigine-13C7,15N
  • HY-W014531S
    2,6-Dichloro-4-nitrophenol-13C6

    		Isotope-Labeled Compounds Others
    2,6-Dichloro-4-nitrophenol-sup>13C6 is the 13C-labeled 2,6-Dichloro-4-nitrophenol.
    2,6-Dichloro-4-nitrophenol-13C6
  • HY-W074977S
    2,6-Dibromo-4-nitrophenol-13C6

    		Isotope-Labeled Compounds Others
    2,6-Dibromo-4-nitrophenol-sup>13C6 is the 13C-labeled 2,6-Dibromo-4-nitrophenol.
    2,6-Dibromo-4-nitrophenol-13C6
  • HY-D1583
    Cyanine5 DBCO hexafluorophosphate
    3 Publications Verification

    DBCO-Cy5 hexafluorophosphate; Cyanine5 dibenzocyclooctyne hexafluorophosphate

    		 Fluorescent Dye Others
    Cyanine5 DBCO (DBCO-Cy5) hexafluorophosphate is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO hexafluorophosphate has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO hexafluorophosphate can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm) [2].
    Cyanine5 DBCO hexafluorophosphate
  • HY-B2156S1
    Menaquinone-4-13C6

    Vitamin K2(MK-4)-<sup>13sup>C6; MeNaquinone K4-<sup>13sup>C6

    		 Isotope-Labeled Compounds Endogenous Metabolite Cancer
    Menaquinone-4- 13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
    Menaquinone-4-13C6
  • HY-P1604
    ATX-II

    		Sodium Channel Inflammation/Immunology
    ATX-II is a specific Na + channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II causes delayed inactivation of the Na +sup channel in cell cultures. ATX-II sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II also induces pulmonary vein arrhythmogenesis and atrial fibrillation .
    ATX-II
  • HY-N8859
    Isoiridogermanal

    16-Hydroxyiridal

    		 Others Others
    Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against MCF-7 and C32 cell lines.
    Isoiridogermanal
  • HY-B0495S7
    Lamotrigine-13C

    LTG-<sup>13sup>C; BW430C-<sup>13sup>C

    		 Isotope-Labeled Compounds Neurological Disease Cancer
    Lamotrigine- 13C (LTG- 13C) is 13C labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .
    Lamotrigine-13C
  • HY-156383
    SCO-PEG3-NHS

    		PROTAC Linkers Cancer
    SCO-PEG3-NHS is a PEG linker with a terminal imine(NH) group. SCO-PEG3-NHS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    SCO-PEG3-NHS
  • HY-B0211S
    Riluzole-13C,15N2

    PK 26124-<sup>13sup>C,<sup>15sup>N2

    		 GABA Receptor Sodium Channel Neurological Disease
    Riluzole- 13C, 15N2 is the 13C and 15N labeled Riluzole . Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM .
    Riluzole-13C,15N2
  • HY-P1604A
    ATX-II TFA

    		Sodium Channel Inflammation/Immunology
    ATX-II TFA is a specific Na + channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). ATX-II TFA causes delayed inactivation of the Na +sup channel in cell cultures. ATX-II TFA sensitizes skeletal muscle to Halothane (HY-B1010), Caffeine, and Ryanodine (HY-103306). ATX-II TFA also induces pulmonary vein arrhythmogenesis and atrial fibrillation .
    ATX-II TFA
  • HY-D1327
    Cyanine3 azide chloride
    1 Publications Verification

    		 Fluorescent Dye Others
    Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λex=684 nm, λem=710 nm) [1]sup >. Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Cyanine3 azide chloride
  • HY-W011683S2
    2'-Deoxyadenosine monohydrate-3′-13C

    		Isotope-Labeled Compounds Endogenous Metabolite Nucleoside Antimetabolite/Analog Caspase Apoptosis Metabolic Disease Endocrinology Cancer
    2'-Deoxyadenosine monohydrate-3′- 13C is the 13C labeled 2'-Deoxyadenosine monohydrate (HY-W011683) [1] 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer>
    2'-Deoxyadenosine monohydrate-3′-13C
  • HY-B0495S4
    Lamotrigine-13C3

    LTG-<sup>13sup>C3; BW430C-<sup>13sup>C3

    		 Sodium Channel Autophagy Neurological Disease
    Lamotrigine- 13C3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .
    Lamotrigine-13C3
  • HY-A0042S1
    Rufinamide-15N,d2

    CGP 33101-<sup>15sup>N,d2; E 2080-<sup>15sup>N,d2; RUF 331-<sup>15sup>N,d2

    		 Isotope-Labeled Compounds Sodium Channel Neurological Disease
    Rufinamide- 15N,d2 (CGP 33101- 15N,d2) is the deuterium and 15N labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na + current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome .
    Rufinamide-15N,d2
  • HY-N0733S2
    Glucosamine-13C,15N hydrochloride

    D-(+)-Glucosamine-<sup>13sup>C,<sup>15sup>N hydrochloride; Chitosamine-<sup>13sup>C,<sup>15sup>N hydrochloride

    		 Isotope-Labeled Compounds Autophagy Endogenous Metabolite HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Inflammation/Immunology Cancer
    Glucosamine- 13C, 15N (hydrochloride) is the 13C and 15N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, i
    Glucosamine-13C,15N hydrochloride
  • HY-B0271S1
    Pyrazinamide-13C,15N

    Pyrazinecarboxamide-<sup>13sup>C,<sup>15sup>N; Pyrazinoic acid amide-<sup>13sup>C,<sup>15sup>N

    		 Autophagy Antibiotic Bacterial Isotope-Labeled Compounds Infection
    Pyrazinamide- 13C, 15N is 15N and 13C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
    Pyrazinamide-13C,15N
  • HY-N3980
    Guaiol

    Champacol; Guaiac alcohol

    		 Autophagy RAD51 Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions [4]sup .
    Guaiol
  • HY-B0656S1
    Rabeprazole-13C,d3

    LY307640-<sup>13sup>C,d3

    		 Isotope-Labeled Compounds Proton Pump Bacterial Apoptosis Cancer
    Rabeprazole-13C,d3 is a deuterated labeled Rabeprazole . Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux .
    Rabeprazole-13C,d3
  • HY-W778408
    Tamoxifen-13C6

    ICI 47699-<sup>13sup>C6; (Z)-Tamoxifen-<sup>13sup>C6; trans-Tamoxifen-<sup>13sup>C6

    		 Isotope-Labeled Compounds Apoptosis Autophagy HSP Estrogen Receptor/ERR Endocrinology
    Tamoxifen- 13C6 (ICI 47699- 13C6) is the 13C-labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER transgenic mouse .
    Tamoxifen-13C6
  • HY-128436
    KT-531

    		HDAC Cancer
    KT-531 is a potent and selective inhibitor of HDAC6 with an IC50 of 8.5 nM. KT-531 exhibits strong inhibition against SUP-T11 cells with an IC50 of 0.42 μM. KT-531 can be used in study hematological cancers .
    KT-531
  • HY-N8930
    Eupatorin-5-methyl ether

    		Others Others
    Eupatorin-5-methyl ether (TMF) can be isolated from Orthosiphon stamineus. Eupatorin-5-methyl ether is a kind of flavonoid compound. Eupatorin-5-methyl ether inhibits NO production (IC50 5.5 μM).
    Eupatorin-5-methyl ether
  • HY-B0656AS3
    Rabeprazole-13C,d3 sodium

    LY307640-<sup>13sup>C,d3 sodium

    		 Isotope-Labeled Compounds Apoptosis Bacterial Proton Pump Inflammation/Immunology Cancer
    Rabeprazole- 13C,d3 (sodium) (LY307640- 13C,d3 (sodium)) is 13C labeled Rabeprazole (sodium). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H +/K +-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux .
    Rabeprazole-13C,d3 sodium

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