2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Transferases (EC 2)
  5. MAP4K1 Protein, Human (sf9)

MAP4K1 Protein, Human (sf9) is the recombinant human-derived MAP4K1, expressed by Sf9 insect cells , with tag Free labeled tag. ,

For research use only. We do not sell to patients.

Surface Plasmon Resonance (SPR) Assay Service   Protein Expression Service

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  • Biological Activity

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Description

MAP4K1 Protein, Human (sf9) is the recombinant human-derived MAP4K1, expressed by Sf9 insect cells , with tag Free labeled tag. ,
Background

MAP4K1 is a serine/threonine-protein kinase involved in the response to environmental stress. It appears to act upstream of the JUN N-terminal pathway and serves as an activator of the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4K1 functions in parallel to and is partially redundant with STK3/MST2 and STK4/MST1 in phosphorylating and activating LATS1/2, establishing it as a component of the expanded Hippo pathway. It may also play a role in hematopoietic lineage decisions and growth regulation. Additionally, together with CLNK (by similar), it enhances CD3-triggered T-cell activation and subsequent IL2 production.
Species

Human
Source

Sf9 insect cells
Tag

Tag Free
Accession

Q92918-1 (M1-G297)
Gene ID

11184
Protein Length

Partial
Synonyms
MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1
Purity

Greater than 80 % as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

MAP4K1 Protein, Human (sf9) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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MAP4K1 Protein, Human (sf9)
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