Slc12a5/KCC2 Antibody (YA6785)

Cat. No.: HY-P87092: Data Sheet User Guide for Antibodies
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Slc12a5/KCC2 Antibody (YA6785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Slc12a5/KCC2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Slc12a5/KCC2 Antibody (YA6785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Slc12a5/KCC2.

Host

Mouse

Clonality

Recombinant, Monoclonal

Molecular Weight

Predicted band size: 126 kDa;

Observed band size: 150 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Mouse, Rat

SwissProt ID

Q91V14

Gene ID

57138 [NCBI]

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-F IHC-F: Immunohistochemistry-Frozen	1:500 WB: 1:5000

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (By similarity). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (By similarity)

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Cell projection, dendrite

Subunit：Homodimer; adopts a domain-swap conformation at the scissor helices connecting the transmembrane domain and C-terminal domain (PubMed:33597714). Interacts with AP2A1 (PubMed:18625303)

Synonyms

Electroneutral potassium chloride cotransporter 2 antibody; Electroneutral potassium-chloride cotransporter 2 antibody; Erythroid K Cl cotransporter 2 antibody; Furosemide sensitive K Cl cotransporter antibody; hKCC2 antibody; K-Cl cotransporter 2 antibody; KCC 2 antibody; KCC2 antibody; KIAA1176 antibody; Neuronal K Cl cotransporter antibody; Electroneutral potassium chloride cotransporter 2 antibody; Electroneutral potassium-chloride cotransporter 2 antibody; Erythroid K Cl cotransporter 2 antibody; Furosemide sensitive K Cl cotransporter antibody; hKCC2 antibody; K-Cl cotransporter 2 antibody; KCC 2 antibody; KCC2 antibody; KIAA1176 antibody; Neuronal K Cl cotransporter antibody; Neuronal K-Cl cotransporter antibody; Potassium Chloride Cotransporter antibody; Potassium chloride transporter 5 antibody; rKCC2 antibody; S12A5 antibody; S12A5_HUMAN antibody; SLC12A5 antibody; Solute carrier family 12 (potassium chloride transporter) member 5 antibody; Solute carrier family 12 member 5 antibody;

Documentation

User Guide for Antibodies (1077 KB)