2. GPCR/G Protein Neuronal Signaling
  3. GPR119
  4. K-833

K-833 is a GPR119 agonist with EC50 values of 39.8 nM (human), 100nM (mouse), 75.4 nM (rat) and 12.6 nM (dog). K-833 demonstrates a modest increase in GLP-1 secretion and leads to a synergistic increase in GLP-1 levels when combined with AM-5262 (HY-16619) in acute gut peptide secretion assays in mice. K-833 can be used in studies on weight loss.

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K-833

K-833 Chemical Structure

CAS No. : 2639936-77-7

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K-833 Related Antibodies

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Description

K-833 is a GPR119 agonist with EC50 values of 39.8 nM (human), 100nM (mouse), 75.4 nM (rat) and 12.6 nM (dog). K-833 demonstrates a modest increase in GLP-1 secretion and leads to a synergistic increase in GLP-1 levels when combined with AM-5262 (HY-16619) in acute gut peptide secretion assays in mice. K-833 can be used in studies on weight loss[1].

In Vitro

K-833 shows modest antagonism of the human M1 receptor (IC50 = 4.5 μM), inhibition of agonist binding to the human nonselective sigma receptors (IC50 = 2.7 μM) and moderate reversible inhibition of the CYP2B6 (IC50 = 8.6 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

K-833 Related Antibodies
In Vivo

K-833 (30 mg/kg, i.g., single dose) demonstrates a modest increase in GLP-1 secretion in acute gut peptide secretion assays in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 10-12 week old C57BL/6J mice[1]
Dosage: 30 mg/kg or combined with AM-5262 (HY-16619) (30 mg/kg)
Administration: i.g. for a single dose
Result: Led to a modest increase in GLP-1 secretion.
Led to a synergistic increase in GLP-1 levels when combined with AM-5262.
Molecular Weight

640.14

Formula

C30H43ClFN5O7
CAS No.
SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNCC1CN(C(CC2=CC=C(OCCCC3CCN(C4=NC=C(Cl)C=N4)CC3)C=C2F)=O)C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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K-833 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-8332639936-77-7K833K 833GPR119G Protein-Coupled Receptor 119Inhibitorinhibitorinhibit

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