Anticancer agent 110

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Anticancer agent 110 is an anticancer agent with in vitro anticancer activity and excellent anti-leukemia potency. Anticancer agent 110 is highly cytotoxic to K-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. Anticancer agent 110 causes DNA damage and leads to apoptosis.

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Anticancer agent 110 Chemical Structure

CAS No. : 887349-03-3

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
CAKI-1	IC₅₀	772 nM Compound: 3d	Inhibition of cell growth in human CAKI-1 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human CAKI-1 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
HCT-15	IC₅₀	347 nM Compound: 3d	Inhibition of cell growth in human HCT-15 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human HCT-15 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
HaCaT	IC₅₀	> 100 μM Compound: 3d	Antiproliferative activity against human HaCaT cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human HaCaT cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 36809707]
J774.2	IC₅₀	70.67 μM Compound: 3d	Antiproliferative activity against J774.2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against J774.2 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 36809707]
K562	IC₅₀	0.7 μM Compound: 3d	Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 36809707]
K562	IC₅₀	56.4 nM Compound: 3d	Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human K562 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
KM12	IC₅₀	927 nM Compound: 3d	Inhibition of cell growth in human KM12 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human KM12 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
LOX IMVI	IC₅₀	206 nM Compound: 3d	Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human LOX IMVI cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
M14	IC₅₀	261 nM Compound: 3d	Inhibition of cell growth in human M14 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human M14 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
NCI-H460	IC₅₀	993 nM Compound: 3d	Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human NCI-H460 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
NIH3T3	IC₅₀	> 100 μM Compound: 3d	Antiproliferative activity against NIH3T3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against NIH3T3 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 36809707]
SW-620	IC₅₀	118 nM Compound: 3d	Inhibition of cell growth in human SW-620 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human SW-620 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
T47D	IC₅₀	896 nM Compound: 3d	Inhibition of cell growth in human T47D cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human T47D cells incubated for 48 hrs by SRB assay	[PMID: 36809707]
UACC-62	IC₅₀	56.9 nM Compound: 3d	Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB assay Inhibition of cell growth in human UACC-62 cells incubated for 48 hrs by SRB assay	[PMID: 36809707]

In Vitro

Anticancer agent 110 (compound 3d) (0.01 μM-100 μM) inhibits leukemia K-562 cells with IC₅₀ of 0.7 μM^[1].
Anticancer agent 110 (70 nM, 700 nM; 24 h) causes a higher level of DNA damage in K-562 cells^[1].
Anticancer agent 110 (70 nM, 700 nM; 24 h) induces pro-apoptotic changes in the morphology of leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

380.40

Formula

C₁₈H₁₃FN₆OS

CAS No.

887349-03-3

SMILES

O=C(C1=CC=C(N2N=NN=C2)C=C1)NC3=NC=C(CC4=CC=C(C=C4)F)S3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pokhodylo N, et al. Bioisosteric replacement of 1H-1,2,3-triazole with 1H-tetrazole ring enhances anti-leukemic activity of (5-benzylthiazol-2-yl)benzamides. Eur J Med Chem. 2023 Mar 15;250:115126. [Content Brief]