Ginsenoside Rg4 

Ginsenoside Rg4 is an orally active protopanaxatriol type ginsenoside. Ginsenoside Rg4 can activate PI3K, AKT and GSK-3β signaling. Ginsenoside Rg4 can inhibit ROS and inflammatory cytokine levels. Ginsenoside Rg4 can be used for the researches of inflammation, infection and metabolic disease, such as sepsis and lung inflammation^[1][2][3].

Ginsenoside Rg4 (0.01-0.2 mg/mL, 6 h) decreases the expressions of toll-like receptor (TLR) 4 and TNF-α levels in HMGB1-activated HUVECs^[1].
Ginsenoside Rg4 (0.1-0.2 mg/mL, 6 h) increases cell viability by activating PI3K/AKT signaling in HMGB1-activated HUVECs^[1].
Ginsenoside Rg4 (20-50 μg/mL, 48 h) promotes the hair-inductive properties of DP cells by activating the AKT/GSK3β/β-catenin signaling pathway in dermal papilla (DP) sphere^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ginsenoside Rg4 (10-15 mg/kg, i.v., 24 h after CLP) inhibits inflammation and prolongs survival in cecal ligation and puncture (CLP)-induced sepsis mice models^[1].
Ginsenoside Rg4 (1-15 mg/kg, p.o., for 10 days) attenuates inflammation in PM_2.5-induced pulmonary inflammation mice models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

767.00

C₄₂H₇₀O₁₂

126223-28-7

Solid

White to off-white

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Shipping with dry ice.

-80°C, protect from light

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.

• [1]. Kim GO, et al. Inhibitory Activities of Rare Ginsenoside Rg4 on Cecal Ligation and Puncture-Induced Sepsis. Int J Mol Sci. 2022 Sep 16;23(18):10836.  [Content Brief]

  [2]. Lee YH, et al. Ginsenoside Rg4 Enhances the Inductive Effects of Human Dermal Papilla Spheres on Hair Growth Via the AKT/GSK-3β/β-Catenin Signaling Pathway. J Microbiol Biotechnol. 2021 Jul 28;31(7):933-941.  [Content Brief]

  [3]. Wonhwa Lee, et al. Pulmonary Protective Functions of Rare Ginsenoside Rg4 on Particulate Matter-induced Inflammatory Responses. Biotechnology and Bioprocess Engineering 24: 445-453 (2019).