Ionotropic Glutamate Receptor 2 Antibody (YA4014)

Ionotropic Glutamate Receptor 2 Antibody (YA4014) is a mouse-derived and non-conjugated IgG2b antibody, targeting to GRIA2. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.

GRIA2 is an ionotropic glutamate receptor that functions as a ligand-gated cation channel, activated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays a key role in fast excitatory synaptic transmission. Binding of the excitatory neurotransmitter L-glutamate induces a conformational change, leading to the opening of the cation channel, thereby converting the chemical signal into an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then rapidly desensitizes and enters a transient inactive state (By similarity). In the presence of CACNG4, CACNG7, or CACNG8, it exhibits resensitization, characterized by a delayed accumulation of current flux upon continued application of L-glutamate (By similarity). Through complex formation with NSG1, GRIP1, and STX12, it controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

P42262

Predicted band size: 99 kDa; Observed band size: 99 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Purified recombinant fragment of human GRIA2 (AA: 35-175) expressed in E. Coli.