2. Others Immunology/Inflammation NF-κB Membrane Transporter/Ion Channel
  3. NF-κB Reference Standards Sodium Channel NOD-like Receptor (NLR)
  4. Articaine (Standard)

Articaine (Standard)  (Synonyms: Hoe-045 free base (Standard))

Cat. No.: HY-B0516AR
Handling Instructions Technical Support

Articaine (Standard) is the analytical standard of Articaine (HY-B0516A). This product is intended for research and analytical applications. Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 μM for open-state Na+ channels, and IC50 of 40.6 μM and 378 μM for inactivated and resting-state Na+ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury).

For research use only. We do not sell to patients.

Articaine (Standard)

Articaine (Standard) Chemical Structure

CAS No. : 23964-58-1

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Information

Articaine (Standard) is the analytical standard of Articaine (HY-B0516A). This product is intended for research and analytical applications. Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 μM for open-state Na+ channels, and IC50 of 40.6 μM and 378 μM for inactivated and resting-state Na+ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury).

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

284.37

Formula

C13H20N2O3S
CAS No.
SMILES

O=C(C(C)NCCC)NC(C(C)=CS1)=C1C(OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Articaine (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Articaine (Standard)23964-58-1Hoe-045 free base (Standard)NF-κBReference StandardsSodium ChannelNOD-like Receptor (NLR)Nuclear factor-κBNuclear factor-kappaBNa channelsNa+ channelsAmidepain reliefkidney injuryLPSInhibitorinhibitorinhibit

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