2. Membrane Transporter/Ion Channel Neuronal Signaling MAPK/ERK Pathway GPCR/G Protein Immunology/Inflammation Autophagy
  3. Calcium Channel Ras STING Autophagy
  4. Fendiline hydrochloride (Standard)

Fendiline hydrochloride (Standard) 

Cat. No.: HY-B0984R Purity: ≥98%
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Fendiline (hydrochloride) (Standard) is the analytical standard of Fendiline (hydrochloride). This product is intended for research and analytical applications. Fendiline hydrochloride, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker (IC50 of 17 µM). Fendiline hydrochloride is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline hydrochloride inhibits K-Ras plasma membrane localization (IC50 of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline hydrochloride is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10).

For research use only. We do not sell to patients.

Fendiline hydrochloride (Standard) Chemical Structure

Fendiline hydrochloride (Standard) Chemical Structure

CAS No. : 13636-18-5

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Description

Fendiline (hydrochloride) (Standard) is the analytical standard of Fendiline (hydrochloride). This product is intended for research and analytical applications. Fendiline hydrochloride, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker (IC50 of 17 µM). Fendiline hydrochloride is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline hydrochloride inhibits K-Ras plasma membrane localization (IC50 of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline hydrochloride is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10).

Molecular Weight

351.91

Formula

C23H26ClN
CAS No.
SMILES

CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2)C3=CC=CC=C3.[H]Cl
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Fendiline hydrochloride (Standard) Related Classifications

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Keywords:

Fendiline hydrochloride (Standard)13636-18-5Calcium ChannelRasSTINGAutophagyCa2+ channelsCa channelsStimulator of Interferon GenesTMEM173MITAERISMPYSantianginal agentL-type calcium channelK-RasMC38CT26 and B16F10Inhibitorinhibitorinhibit

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