2. Neuronal Signaling Immunology/Inflammation GPCR/G Protein Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Histamine Receptor Potassium Channel Endogenous Metabolite
  4. Dimethindene

Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents.

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Dimethindene

Dimethindene Chemical Structure

CAS No. : 5636-83-9

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Based on 1 publication(s) in Google Scholar

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Dimethindene Related Antibodies

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Description

Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents[1][2].

In Vitro

Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dimethindene Related Antibodies
In Vivo

Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice with skin WH[1]
Dosage: 0.25 mg
Administration: intraperitoneal injection; once
Result: Delayed skin wound closure as compared to vehicle treated mice.
Molecular Weight

292.42

Formula

C20H24N2
CAS No.
Appearance

Powder

SMILES

CC(C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (427.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4197 mL 17.0987 mL 34.1974 mL
5 mM 0.6839 mL 3.4197 mL 6.8395 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4197 mL 17.0987 mL 34.1974 mL 85.4935 mL
5 mM 0.6839 mL 3.4197 mL 6.8395 mL 17.0987 mL
10 mM 0.3420 mL 1.7099 mL 3.4197 mL 8.5493 mL
15 mM 0.2280 mL 1.1399 mL 2.2798 mL 5.6996 mL
20 mM 0.1710 mL 0.8549 mL 1.7099 mL 4.2747 mL
25 mM 0.1368 mL 0.6839 mL 1.3679 mL 3.4197 mL
30 mM 0.1140 mL 0.5700 mL 1.1399 mL 2.8498 mL
40 mM 0.0855 mL 0.4275 mL 0.8549 mL 2.1373 mL
50 mM 0.0684 mL 0.3420 mL 0.6839 mL 1.7099 mL
60 mM 0.0570 mL 0.2850 mL 0.5700 mL 1.4249 mL
80 mM 0.0427 mL 0.2137 mL 0.4275 mL 1.0687 mL
100 mM 0.0342 mL 0.1710 mL 0.3420 mL 0.8549 mL
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Dimethindene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethindene5636-83-9Histamine ReceptorPotassium ChannelEndogenous MetaboliteKcsAcutaneous wound healingK+ currentsfollicle-enclosed Xenopus oocytesInhibitorinhibitorinhibit

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