2. Apoptosis Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Metabolic Enzyme/Protease
  3. DAPK DYRK PDGFR IPK Superfamily
  4. UNC9750

UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC50 values ​​of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP5, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP7 levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR). UNC9750 can be used for the study of glioblastoma.

For research use only. We do not sell to patients.

UNC9750

UNC9750 Chemical Structure

CAS No. : 2967648-29-7

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UNC9750 Related Antibodies

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Description

UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC50 values ​​of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP5, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP7 levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR). UNC9750 can be used for the study of glioblastoma[1].

IC50 & Target[1]

DYRK1B

 

DAPK1

 

PDGFR

 

PDGFR2

 

In Vitro

UNC9750 (Compound 14) (0-10 μM, 48-72 h) decreases human glioblastoma cell U251-MG growth and selectively reduces cellular InsP5 abundance but does not decrease InsP6 or InsP7 levels after 72 h[1].
UNC9750 (1 μM) has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR[1].
UNC9750 (10-50 μM, 24 h) can significantly and concentration-dependently upregulate the expression of SF-1 target gene CYP11A1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UNC9750 Related Antibodies
Parmacokinetics[1]
Species Dose Route Indicator value
Mice 2.75 mg/kg i.v. T1/2 1.95 h
Mice 2.75 mg/kg i.v. Cmax 28.3 μM
Mice 2.75 mg/kg i.v. AUClast 4.6 μM·h
Mice 2.75 mg/kg i.v. Vss 0.39 L/kg
Mice 2.75 mg/kg i.v. CL 22.8 mL/min/kg
Molecular Weight

400.48

Formula

C23H24N6O
CAS No.
SMILES

C1(C2=NN=NN2)=CC3=C(ON=C3C=C1)C4=CC(C5CCN(CC5)C6CCC6)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UNC9750 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC97502967648-29-7UNC 9750UNC-9750DAPKDYRKPDGFRIPK SuperfamilyDeath associated protein kinaseDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinasePlatelet-derived growth factor receptorInositiol Polyphosphate Kinase (IPK) SuperfamilyU251-MG glioblastoma cellsInositol phosphate metabolismInhibitorinhibitorinhibit

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