Phospho-Rac1/CDC42 (Ser71) Antibody (YA2604)

Phospho-Rac1/CDC42 (Ser71) Antibody (YA2604) is a non-conjugated IgG antibody, targeting Phospho-Rac1/CDC42 (Ser71), with a predicted molecular weight of 21 kDa (observed band size: 24 kDa). Phospho-Rac1/CDC42 (Ser71) Antibody (YA2604) can be used for WB experiment in human background.

CDC42, a plasma membrane-associated small GTPase, dynamically transitions between an active GTP-bound state and an inactive GDP-bound state, modulating diverse cellular responses by interacting with various effector proteins. Notably, CDC42 is intricately involved in processes such as epithelial cell polarization, where it plays a critical role in regulating spindle microtubule attachment to kinetochores before chromosome congression in metaphase. Additionally, CDC42 influences cell migration and is pivotal for the extension and maintenance of filopodia, slender actin-rich projections, in neurons. In the context of neuronal plasticity, it participates in CaMKII-mediated signaling, impacting dendritic spine structural plasticity and contributing to long-term synaptic changes. Moreover, CDC42 is essential for the formation of spines in specific neuronal cell types, such as Purkinje cells and hippocampal neurons, through interactions with DOCK10 and DOCK11. In podocytes, it facilitates the formation of filopodia and podosomes upon activation by DOCK11. Furthermore, CDC42 plays a crucial role in the orchestration of F-actin cytoskeleton dynamics during phagocytosis, contributing to the formation of phagocytic cups. This multifaceted engagement underscores the versatility of CDC42 in regulating various cellular functions.

P60953

Predicted band size: 21 kDa; Observed band size: 24 kDa

Affinity Chromatography

Non-conjugated

Phosphorylated

AB_3104952

Cell Biology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

WB: 1/500-1/1000

WB

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human Phospho-Rac1/Cdc42 (Ser71)