2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling Immunology/Inflammation
  3. JAK Interleukin Related STAT
  4. Patiromer

Patiromer is an orally active, selective and non-absorbable intestinal potassium (K+) polymer binder that reversibly binds potassium ions in exchange for calcium (Ca2+). Patiromer can rapidly and continuously reduce serum potassium levels, maintain a normal blood potassium state, and reduce serum aldosterone levels. Patiromer also increases fecal potassium excretion. Patiromer is mainly used in the study of hyperkalemia associated with diseases such as chronic kidney disease, diabetes, and heart failure, and is particularly suitable for improving renin-angiotensin-aldosterone system inhibitor (RAASi) therapy.

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Patiromer Chemical Structure

Patiromer Chemical Structure

CAS No. : 1208912-84-8

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Based on 1 publication(s) in Google Scholar

Patiromer Related Antibodies

Top Publications Citing Use of Products

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JAK1 JAK2 JAK3 Tyk2 JAK

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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STAT3 STAT5 STAT6 STAT1

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Description

Patiromer is an orally active, selective and non-absorbable intestinal potassium (K+) polymer binder that reversibly binds potassium ions in exchange for calcium (Ca2+). Patiromer can rapidly and continuously reduce serum potassium levels, maintain a normal blood potassium state, and reduce serum aldosterone levels. Patiromer also increases fecal potassium excretion. Patiromer is mainly used in the study of hyperkalemia associated with diseases such as chronic kidney disease, diabetes, and heart failure, and is particularly suitable for improving renin-angiotensin-aldosterone system inhibitor (RAASi) therapy[1][2][3].

IC50 & Target

JAK3

33.1 nM (IC50)

IL-2

 

IL-4

 

IL7R

 

IL-15

 

STAT3

 

STAT5

 

STAT6

 

In Vitro

Patiromer is a sodium-free, non-absorbable K+ binding polymer[2].
Patiromer has a significantly higher potassium binding capacity in vitro than traditional resins such as polystyrene sulfonate and has high-capacity potassium binding properties[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Patiromer Related Antibodies
In Vivo

Patiromer (4 g/kg; oral gavage; once daily; 8 days or 12 weeks) significantly reduces serum K+ and aldosterone levels in a unilaterally nephrectomized male spontaneously hypertensive rat model with induced chronic hyperkalemia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spontaneously hypertensive rats (SHR) (male, 200-250 g, 7-9 weeks old) with unilateral nephrectomy (UniNx)[2]
Dosage: 4 g/kg
Administration: Oral gavage, once daily, 8 days; rats were induced chronic hyperkalemia by 3% potassium diet and amiloride.
Result: Significantly reduced serum K+ from baseline at days 4 and 8, and serum aldosterone was reduced to baseline levels, with no significant clinical distress in animals.
Clinical Trial
Formula

C28H48CaFO2+
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CCC(C([O-])=O)(F)CC(C1=CC=CC=C1)CC(CCCCC(C)CC)C.CC(CC)C.[Ca+2].[p].[p].[n].[m].[n].[1/2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at 4°C, do not freeze
Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

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Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (231 KB)

Handling Instructions (2659 KB)
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Patiromer Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Patiromer1208912-84-8JAKInterleukin RelatedSTATJanus kinaseILelectrolyte disorderdialysisheart failurehyperkalemiahypertensionpatiromerpotassiumkidney diseaseInhibitorinhibitorinhibit

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