EHMT1 Antibody (YA4824)

EHMT1 Antibody (YA4824) is a mouse-derived and non-conjugated monoclonal antibody, targeting to EHMT1. It can be applicated for WB, ELISA assays, in the background of human.

EHMT1 is a histone methyltransferase that specifically mono- and dimethylates lysine 9 of histone H3 (H3K9me1 and H3K9me2) in euchromatin. H3K9me serves as an epigenetic mark for transcriptional repression by recruiting HP1 proteins to methylated histones. It also weakly methylates lysine 27 of histone H3 (H3K27me) and is involved in DNA methylation (with its histone methyltransferase activity functioning independently of DNA methylation). Likely targeted to histone H3 by DNA-binding proteins such as E2F6, MGA, MAX, or DP1, it contributes to silencing MYC- and E2F-responsive genes during G0 phase, implicating a role in G0/G1 transition regulation. Beyond histone methylation, EHMT1 dimethylates non-histone proteins (e.g., lysine 373 of p53/TP53) and represses mitochondrial function-related genes, potentially through promoter occupancy in concert with BAZ2B (by similarity).

Q9H9B1

Predicted band size: 141 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of EHMT1 expressed in E. Coli.