2. Others Autophagy PI3K/Akt/mTOR Epigenetics Apoptosis Stem Cell/Wnt JAK/STAT Signaling Immunology/Inflammation TGF-beta/Smad MAPK/ERK Pathway NF-κB Metabolic Enzyme/Protease
  3. Reference Standards Autophagy mTOR AMPK Apoptosis STAT Interleukin Related PKC p38 MAPK NF-κB COX Reactive Oxygen Species (ROS) PI3K Akt MMP
  4. Phellodendrine chloride (Standard)

Phellodendrine chloride (Standard) is the analytical standard of Phellodendrine chloride (HY-N0735). Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway.

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Phellodendrine chloride (Standard)

Phellodendrine chloride (Standard) Chemical Structure

CAS No. : 104112-82-5

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Phellodendrine chloride (Standard) is the analytical standard of Phellodendrine chloride (HY-N0735). Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway.

Molecular Weight

377.86

Formula

C20H24ClNO4
CAS No.
SMILES

C[N@@+]12CCC3=CC(OC)=C(O)C=C3[C@]1([H])CC4=CC(O)=C(OC)C=C4C2.[Cl-]
Structure Classification
Initial Source
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Keywords:

Phellodendrine chloride (Standard)104112-82-5Reference StandardsAutophagymTORAMPKApoptosisSTATInterleukin RelatedPKCp38 MAPKNF-κBCOXReactive Oxygen Species (ROS)PI3KAktMMPMammalian target of RapamycinAMP-activated protein kinaseILProtein kinase CNuclear factor-κBNuclear factor-kappaBCyclooxygenasePhosphoinositide 3-kinasePKBProtein kinase BMatrix metalloproteinasesKRAS mutated pancreatic cancersMacropinocytosisGlutamine metabolismMitochondrial apoptosis AutophagyNetwork pharmacologyPhellodendrineUlcerative colitisInhibitorinhibitorinhibit

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