2. Anti-infection PI3K/Akt/mTOR
  3. Bacterial PI3K Akt
  4. Vasicine hydrochloride

Vasicine hydrochloride  (Synonyms: Peganine hydrochloride)

Cat. No.: HY-N1103A Purity: 98.62%
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Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine hydrochloride activates PI3K/Akt signaling pathway, exhibits antioxidant, anti-inflammatory and antibacterial activities.

For research use only. We do not sell to patients.

Vasicine hydrochloride Chemical Structure

Vasicine hydrochloride Chemical Structure

CAS No. : 7174-27-8

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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

Other Forms of Vasicine hydrochloride:

Vasicine hydrochloride Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

  • Biological Activity

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  • References

  • Customer Review

Description

Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine hydrochloride activates PI3K/Akt signaling pathway, exhibits antioxidant, anti-inflammatory and antibacterial activities[1][2][3].

In Vitro

Vasicine hydrochloride (10-100 μg/mL, 10 min) exhibits a moderate inhibitory activity against H+/K+-ATPase (IC50=73.47 μg/mL), scavenges DPPH free radical (IC50=71.97 μg/mL), reduces gastric acid secretion and exhibits anti-ulcer effect[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vasicine hydrochloride Related Antibodies
In Vivo

Vasicine hydrochloride (2.5-10 mg/kg, po, once daily for 7 days) improves the cardiac function, inhibits myocardial cell apoptosis, and alleviates myocardial necrosis, edema, and inflammatory cell infiltration in Isoproterenol (HY-B0468)-induced rats myocardial infarction models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Isoproterenol-induced rats myocardial infarction models[2]
Dosage: 2.5-10 mg/kg
Administration: po, once daily for 7 days
Result: Reduced the levels of serum lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB).
Increased left ventricular systolic pressure (LVSP) and myocardial contractility, and reduced infarct size.
Reduced the levels of serum TNF-α and IL-6.
Increased the activities of SOD and glutathione peroxidase (GPx) in myocardial tissue, reduced the levels of MDA and MPO.
Increased the thickness of the left ventricular posterior wall and the left ventricular mass.
Inhibited myocardial cell apoptosis.
Molecular Weight

224.69

Formula

C11H13ClN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1CCN2C1=NC3=C(C=CC=C3)C2.[H]Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Vasicine hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vasicine7174-27-8PeganineBacterialPI3KAktPhosphoinositide 3-kinasePKBProtein kinase BInhibitorinhibitorinhibit

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