2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB 206553

SB 206553 is a 5-HT2C inverse agonist. SB 206553 can attenuate methamphetamine-seeking in rats. SB 206553 has activity for 5-HT2 receptor ligands in HEK-293 or CHO-K1 cells expressing human recombinant 5-HT2 receptors with pKi values of 5.6 nM (5-HT2A), 7.7 nM (5-HT2B) and 7.8 nM (5-HT2C), respectively. SB 206553 can be used for the research of psychostimulant abuse disorders.

For research use only. We do not sell to patients.

SB 206553 Chemical Structure

SB 206553 Chemical Structure

CAS No. : 158942-04-2

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Based on 1 publication(s) in Google Scholar

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SB 206553 Related Antibodies

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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Description

SB 206553 is a 5-HT2C inverse agonist. SB 206553 can attenuate methamphetamine-seeking in rats. SB 206553 has activity for 5-HT2 receptor ligands in HEK-293 or CHO-K1 cells expressing human recombinant 5-HT2 receptors with pKi values of 5.6 nM (5-HT2A), 7.7 nM (5-HT2B) and 7.8 nM (5-HT2C), respectively. SB 206553 can be used for the research of psychostimulant abuse disorders[1].

IC50 & Target

5-HT2A Receptor

 

5-HT2B Receptor

 

5-HT2C Receptor

 

Molecular Weight

292.34

Formula

C17H16N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCC2=C1C=C3C(N(C)C=C3)=C2)NC4=CC=CN=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (342.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4207 mL 17.1034 mL 34.2067 mL
5 mM 0.6841 mL 3.4207 mL 6.8413 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4207 mL 17.1034 mL 34.2067 mL 85.5169 mL
5 mM 0.6841 mL 3.4207 mL 6.8413 mL 17.1034 mL
10 mM 0.3421 mL 1.7103 mL 3.4207 mL 8.5517 mL
15 mM 0.2280 mL 1.1402 mL 2.2804 mL 5.7011 mL
20 mM 0.1710 mL 0.8552 mL 1.7103 mL 4.2758 mL
25 mM 0.1368 mL 0.6841 mL 1.3683 mL 3.4207 mL
30 mM 0.1140 mL 0.5701 mL 1.1402 mL 2.8506 mL
40 mM 0.0855 mL 0.4276 mL 0.8552 mL 2.1379 mL
50 mM 0.0684 mL 0.3421 mL 0.6841 mL 1.7103 mL
60 mM 0.0570 mL 0.2851 mL 0.5701 mL 1.4253 mL
80 mM 0.0428 mL 0.2138 mL 0.4276 mL 1.0690 mL
100 mM 0.0342 mL 0.1710 mL 0.3421 mL 0.8552 mL
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SB 206553 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB 206553158942-04-2SB206553SB-2065535-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT2Cmethamphetaminepsychostimulant abuse disordersInhibitorinhibitorinhibit

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