Phospho-MAPKAPK2 (Thr334) Antibody

Phospho-MAPKAPK2 (Thr334) Antibody is a rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to phosphorylated MAPKAPK2 (Thr334). It can be applicated for assays in the background of human, mouse, rat.

MAPKAPK2 protein is a stress-activated serine/threonine-protein kinase with a multifaceted role in cellular processes. It participates in cytokine production, endocytosis, cytoskeleton reorganization, cell migration, cell cycle control, chromatin remodeling, DNA damage response, and transcriptional regulation. Upon stress, MAPKAPK2 is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to the phosphorylation of various substrates. It phosphorylates serine in specific peptide sequences and targets proteins involved in diverse cellular functions. Notably, MAPKAPK2 mediates the inflammatory response by regulating the post-transcriptional aspects of tumor necrosis factor (TNF) and IL6 production. It accomplishes this by phosphorylating AU-rich element (ARE)-binding proteins, affecting mRNA stability and translation. Additionally, MAPKAPK2 plays a crucial role in the late G2/M checkpoint following DNA damage, contributing to post-transcriptional mRNA stabilization. Its involvement in the toll-like receptor signaling pathway in dendritic cells underscores its significance in immune responses. Overall, MAPKAPK2 emerges as a key player in orchestrating cellular responses to stress and various signaling pathways.

P49137

Predicted band size: 65 kDa；Observed band size: 65 kDa

Affinity Purified

Non-conjugated

Phosphorylated

Primary Antibody; Rabbit Polyclonal Antibody

Polyclonal

Rabbit

Human, Mouse, Rat

WB: 1/500-1/1000; IHC: 1/50-1/100; ICC: 1/100-1/200

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Synthetic peptide of human MAPKAPK2