2. Epigenetics
  3. Histone Methyltransferase
  4. UNC8153

UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2.

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UNC8153 Chemical Structure

UNC8153 Chemical Structure

CAS No. : 2929304-60-7

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Based on 1 publication(s) in Google Scholar

Other Forms of UNC8153:

UNC8153 Related Antibodies

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View All Histone Methyltransferase Isoform Specific Products:

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].

In Vitro

UNC8153 (0-20 μM, 96 h) exhibits anti-adhesion effect in KMS11 cell, and exhibits mild cytotoxicity against MM1S cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UNC8153 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MM1S
Concentration: 0-50 μM
Incubation Time: 96 h
Result: Inhibited the cell proliferation.
Molecular Weight

583.68

Formula

C33H37N5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C2NC(COC2=C1)=O)N(CC3=CC=C(C(NC4=CC=C(C(NCCCCCCN)=O)C=C4)=O)C=C3)C5CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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UNC8153 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC81532929304-60-7UNC 8153UNC-8153Histone MethyltransferaseNSD2 degraderH3K36me2proteasome-dependent degradation of NSD2antiproliferative effectsantiadhesive effectsInhibitorinhibitorinhibit

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