2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Flindokalner (Standard)

Flindokalner (Standard) is the analytical standard of Flindokalner. This product is intended for research and analytical applications. Flindokalner (BMS-204352) is a potassium channel modulator. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is also a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors. Flindokalner shows anxiolytic efficacy in vivo.

For research use only. We do not sell to patients.

Flindokalner (Standard) Chemical Structure

Flindokalner (Standard) Chemical Structure

CAS No. : 187523-35-9

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flindokalner (Standard)187523-35-9Potassium ChannelKcsAneuronalsubtypeanxiolyticcurrentventricularmyocyteseffectsInhibitorinhibitorinhibit

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