2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Protease Activated Receptor (PAR) Thrombin
  4. Thrombin, Pig blood

Rabbit Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.

For research use only. We do not sell to patients.

Thrombin, Pig blood Chemical Structure

Thrombin, Pig blood Chemical Structure

CAS No. : 9002-04-4

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100 KU In-stock

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Thrombin, Pig blood Related Antibodies

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Description

Rabbit Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins[1].

In Vitro

Thrombin, Pig blood is a key enzyme in the coagulation cascade, responsible for converting fibrinogen into fibrin. Thrombin, Pig blood activates platelet activation, endothelial cell function, and inflammatory responses by binding to PAR-1 and PAR-4, which triggers G protein-coupled signaling pathways. Thrombin, Pig blood holds promise for research in coagulation and inflammation fields[2][3].
Thrombin, Pig blood exhibits a good affinity to thrombomodulin TM456 with a KD of 1.6 nM, which converts the procoagulant activity of Thrombin, Pig blood into anticoagulant and antiplasmin properties[4].
Thrombin, Pig blood induces PAR1-related intracellular Ca2+ release in cell MDA-MB 231 and A549 with EC50s of 2.57 nM and 0.53 nM[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thrombin, Pig blood Related Antibodies
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Thrombin, Pig blood]
EC Number

3.4.21.5
Enzyme Activity

≥100 IU/mg soild
Unit Definition

It was determined by comparison with the Thrombin reference standard
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 88.00%

SDS (251 KB)

COA (230 KB)

Handling Instructions (2659 KB)
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Thrombin, Pig blood Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thrombin, Pig blood9002-04-4Protease Activated Receptor (PAR)ThrombinThrombin receptorscoagulationanti-inflammatoryInhibitorinhibitorinhibit

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