2. Epigenetics TGF-beta/Smad MAPK/ERK Pathway
  3. PKC JNK
  4. Ro 31-8220 mesylate (Standard)

Ro 31-8220 mesylate (Standard) is the analytical standard of Ro 31-8220 mesylate (HY-13866). This product is intended for research and analytical applications. Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC.

For research use only. We do not sell to patients.

Ro 31-8220 mesylate (Standard)

Ro 31-8220 mesylate (Standard) Chemical Structure

CAS No. : 138489-18-6

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25 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
50 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
100 mg Get quote 6 - 7 weeks 5 - 6 weeks 5 - 6 weeks
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Information

Ro 31-8220 mesylate (Standard) is the analytical standard of Ro 31-8220 mesylate (HY-13866). This product is intended for research and analytical applications. Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

553.65

Formula

C26H27N5O5S2
CAS No.
SMILES

NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Ro 31-8220 mesylate (Standard) Related Classifications

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Keywords:

Ro 31-8220 mesylate (Standard)138489-18-6PKCJNKProtein kinase Cc-Jun N-terminal kinaseInhibitorinhibitorinhibit

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