2. Epigenetics TGF-beta/Smad
  3. PKC
  4. Ro 31-8220 mesylate (Standard)

Ro 31-8220 mesylate (Standard) 

Cat. No.: HY-13866R Purity: ≥98%
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Ro 31-8220 (mesylate) (Standard) is the analytical standard of Ro 31-8220 (mesylate). This product is intended for research and analytical applications. Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

For research use only. We do not sell to patients.

Ro 31-8220 mesylate (Standard) Chemical Structure

Ro 31-8220 mesylate (Standard) Chemical Structure

CAS No. : 138489-18-6

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Description

Ro 31-8220 (mesylate) (Standard) is the analytical standard of Ro 31-8220 (mesylate). This product is intended for research and analytical applications. Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

Molecular Weight

553.65

Formula

C26H27N5O5S2
CAS No.
SMILES

NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Ro 31-8220 mesylate (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 31-8220 mesylate (Standard)138489-18-6PKCProtein kinase CInhibitorinhibitorinhibit

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