Ro 31-8220 formic (Synonyms: Bisindolylmaleimide IX formic)

Cat. No.: HY-13866B: Data Sheet Handling Instructions
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Ro 31-8220 formic is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 formic also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively).

For research use only. We do not sell to patients.

Ro 31-8220 formic Chemical Structure

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Other In-stock Forms of Ro 31-8220 formic:

Ro 31-8220 mesylate

Other Forms of Ro 31-8220 formic:

Ro 31-8220 mesylate In-stock
Ro 31-8220 Get quote
Ro 31-8220 mesylate (Standard) Get quote

13 Publications Citing Use of MCE Ro 31-8220 formic

: Ro 31-8220 formic purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Sep 11;9(1):3688. [Abstract]; Levels of phosphorylated FAK and AKT are reduced by the PKN1 inhibitors. Cells are seeded in six-well plates after transfection with PKN1 inhibitors Lestaurtinib and Ro318220 or DMSO as control.

: Ro 31-8220 formic purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2017 Nov;16(5):5924-5930. [Abstract]; The PKC inhibitor Ro 31 8220 is used to investigate the implication of PKC mediated signaling pathways.

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

PKC-α

5 nM (IC₅₀)

PKC-βII

14 nM (IC₅₀)

PKC-βI

24 nM (IC₅₀)

PKC-ε

24 nM (IC₅₀)

PKC-γ

27 nM (IC₅₀)

Rat Brain PKC

23 nM (IC₅₀)

Molecular Weight

503.57

Formula

C₂₆H₂₅N₅O₄S

SMILES

NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.OC=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wilkinson SE, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1;294 (Pt 2):335-7. [Content Brief]

[2]. Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. [Content Brief]

[3]. Tian F, et al. Inhibition of protein kinase C protects against paraoxon-mediated neuronal cell death. Neurotoxicology. 2007 Jul;28(4):843-9. Epub 2007 Apr 20. [Content Brief]

[4]. Hambleton M, et al. Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. Circulation. 2006 Aug 8;114(6):574-82. [Content Brief]

Ro 31-8220 formic Related Classifications

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The molarity calculator equation

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 31-8220Bisindolylmaleimide IXPKCProtein kinase CInhibitorinhibitorinhibit

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