2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. MZH29

MZH29 is a potent and orally active FLT3 inhibitor. MZH29 shows inhibitory effects on wild-type and mutant FLT3, including the FLT3-ITD, FLT3-D835H/Y/V and FLT3-K663Q mutants. MZH29 retains its potent inhibitory effect against the FLT3-ITD/F691L mutation, a drug resistance mutation against the well-known FLT3 inhibitor, AC220 (HY-13001). MZH29 can be used for the research of cancer, such as acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

MZH29

MZH29 Chemical Structure

CAS No. : 2089590-80-5

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Description

MZH29 is a potent and orally active FLT3 inhibitor. MZH29 shows inhibitory effects on wild-type and mutant FLT3, including the FLT3-ITD, FLT3-D835H/Y/V and FLT3-K663Q mutants. MZH29 retains its potent inhibitory effect against the FLT3-ITD/F691L mutation, a drug resistance mutation against the well-known FLT3 inhibitor, AC220 (HY-13001). MZH29 can be used for the research of cancer, such as acute myeloid leukemia (AML)[1].

In Vivo

MZH29 (1 mg/kg, p.o.) causes complete tumor regression and extends survival in a mouse model of AML with less toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

560.62

Formula

C31H33FN4O5
CAS No.
SMILES

O=C(NC1=CC=CC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OCCCN5CCOCC5)=C(OC)C=C34)C(F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MZH29 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MZH292089590-80-5MZH 29MZH-29FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3FLT3-ITDFLT3-D835H/Y/VFLT3-K663QFLT3-ITD/F691Lacute myeloid leukemiaAMLcancerInhibitorinhibitorinhibit

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