KSHV K8a Antibody (YA4606)

KSHV K8a Antibody (YA4606) is a mouse-derived and non-conjugated IgG2a antibody, targeting to KSHV K8a. It can be applicated for WB, ICC, ELISA assays.

KSHV K8a is a SUMO E3 ligase that plays a role in viral gene regulation and is essential for viral reactivation. It disrupts host G1 cell cycle control, allowing viral transcription and translation to proceed at the early stages of infection. The enzyme catalyzes its own SUMO modification as well as that of its interacting partners, such as host TP53 and RB1. KSHV K8a regulates viral gene expression and reactivation and may mediate the SUMOylation of viral promoters in the low methylated 'Lys-9' histone H3 (H3K9me) region, resulting in diminished viral gene expression after reactivation. Additionally, it SUMOylates host histone lysine demethylase 4A/KDM4A, an essential step for complete enrichment of SUMO-2/3 on the viral genome during viral transactivation and reactivation.

Q2HR82

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

IF: 1/25-1/50 ELISA: 1/10000

WB, ICC, ELISA

Liquid

Supplied in ascitic fluid containing 0.03% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Purified recombinant fragment of KSHV K8α expressed in E. Coli.