mGluR1 activator-1 

mGluR1 activator-1 is a stable Vitamin K (HY-B2172) analogue and a mGluR1 activator that can penetrate the blood-brain barrier. mGluR1 activator-1 exhibits strong transcriptional activation via steroid and xenobiotic receptor as well as retinoic acid receptor. mGluR1 activator-1 induces neuronal differentiation in mouse neural progenitor cells. mGluR1 activator-1 can be used for the study of neurodegenerative disease such as Alzheimer’s^[1].

mGluR1 activator-1 (Compound 7) (1 or 10 μM, 48 h) regulates transcriptional activity via SXR and RAR in neural stem cells^[1].
mGluR1 activator-1 (1 μM, 48 h) significantly increases the positive signal of Map2, indicating that it can effectively induce neural progenitor cells to differentiate into neurons^[1].
mGluR1 activator-1 (1-10 μM, 24 h) shows a concentration-dependent increase in cellular uptake in MG63 cells, and can be converted by the cells into a bioactive form Menaquinone-4 (MK-4) (HY-B2156)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

mGluR1 activator-1 (Compound 7) (10 μmol/mL, p.o., single dose) enters the brain earlier than MK-4 and is converted to MK-4 by 24 h after administration in C57BL6J mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

418.52

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• [1]. Hirota Y, et al. A New Class of Vitamin K Analogues Containing the Side Chain of Retinoic Acid Have Enhanced Activity for Inducing Neuronal Differentiation. ACS Chem Neurosci. 2025 Jul 3.  [Content Brief]