ADAR Antibody (YA4102)

ADAR Antibody (YA4102) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ADAR. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human.

ADAR catalyzes adenosine-to-inosine (A-to-I) editing in double-stranded RNA (dsRNA), influencing gene expression through multiple mechanisms: altering protein coding sequences (as inosine is read as guanosine), modulating pre-mRNA splicing, regulating RNA stability, and affecting RNA-structured processes like microRNA biogenesis. It edits both viral (e.g., HCV, HIV-1) and cellular RNAs (e.g., BLCAP, glutamate/serotonin receptors) via site-specific (e.g., GRIA2 R/G site) or hyper-editing modes. ADAR exhibits dual roles in viral infections—pro-viral (enhancing HDV, HIV-1 replication) or antiviral (inhibiting HCV)—through editing-dependent (e.g., HDV amber/W site editing to produce L-HDAg) or independent mechanisms (e.g., suppressing EIF2AK2/PKR for HIV-1). Notably, excessive ADAR activity inhibits HDV replication.

P55265

Predicted band size: 136 kDa; Observed band size: 150 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human ADAR (AA: 1085-1223) expressed in E. Coli.