Cimicifugic acid D  (Synonyms: 2-Caffeoylpiscidic acid)

Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that induces vasodilation of precontracted rat aortic strips and endothelium-independent relaxation mechanism. Cimicifugic acid D inhibits extracellular Ca²⁺ influx through receptor-operated Ca²⁺ channels (ROC) in Norepinephrine (HY-13715)-induced contraction of rat aortic strips, without affecting voltage-dependent Ca²⁺ channels (VDC) or K⁺-induced contractions^[1].

Cimicifugic acid D (300 μM; 1 h; rat aortic strips) causes relaxation of Norepinephrine-precontracted aortic strips, and reduces Norepinephrine-induced concentration-dependent contraction^[1].
Cimicifugic acid D (30 μM; 1 h; rat aortic strips) inhibits Ca²⁺-induced contraction in Norepinephrine-pretreated aortic strips^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

418.35

C₂₀H₁₈O₁₀

219986-51-3

OC(C=C1)=CC=C1C[C@@](C(O)=O)(O)[C@@H](C(O)=O)OC(/C=C/C2=CC(O)=C(C=C2)O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Noguchi M, et al. Vasoactive effects of cimicifugic acids C and D, and fukinolic acid in cimicifuga rhizome. Biol Pharm Bull. 1998 Nov;21(11):1163-8.  [Content Brief]