MEK2 Antibody (YA5431)

MEK2 Antibody (YA5431) is a mouse-derived and non-conjugated monoclonal antibody, targeting to MEK2. It can be applicated for WB assays, in the background of human, rat, mouse.

MEK1 protein, a pivotal component of the MAP kinase signal transduction pathway, plays a crucial role in transducing extracellular signals into intracellular responses. Upon binding of ligands such as growth factors and cytokines to their cell-surface receptors, MEK1 is activated as part of the RAS-RAF1-MEK1/2-MAPK/ERK cascade. MEK1, along with MAP2K2/MEK2, catalyzes the dual phosphorylation of threonine and tyrosine residues in the activation loop of ERK1 and ERK2, thereby initiating downstream signaling events. This cascade regulates diverse biological functions, including cell growth, adhesion, survival, and differentiation. In addition to its role in the transcriptional and cytoskeletal regulation, the MAPK/ERK pathway impacts peroxisome proliferator-activated receptor gamma (PPARG), contributing to cellular processes such as differentiation and apoptosis. Furthermore, MEK1's involvement in endosomal dynamics and Golgi apparatus fragmentation during mitosis underscores its versatility in coordinating intricate cellular responses.

P36507

Observed band size: 45 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Rat, Mouse

WB: 1:500-1:2000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Synthesized peptide derived from human MEK-2 around the non-phosphorylation site of T394.