MANT-dADP trisodium  (Synonyms: 2'-Deoxy-3'-MANT-ADP trisodium)

MANT-dADP (trisodium) (2'-Deoxy-3'-MANT-ADP (trisodium)) is a fluorescent nucleotide derivative, with an emission maximum of 453 nm upon excitation at 350 nm. MANT-dADP (trisodium) can decrease inositol phoshate formation in CHO-K1 cells that express human purinergic P2Y_{12 receptor. MANT-dADP (trisodium) can be studied in research on the interaction between cardiac troponin I and myofibrils^[1][2][3].}

610.29

C₁₈H₁₉N₆Na₃O₁₀P₂

NC(N=CN=C12)=C1N=CN2[C@@H]3O[C@H](COP(OP(O[Na])(O[Na])=O)(O[Na])=O)[C@@H](OC(C4=C(C=CC=C4)NC)=O)C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bujalowski W, et al., Structural characteristics of the nucleotide-binding site of Escherichia coli primary replicative helicase DnaB protein. Studies with ribose and base-modified fluorescent nucleotide analogs. Biochemistry. 1994 Apr 19;33(15):4682-94.  [Content Brief]

  [2]. Schmidt P, et al., Identification of determinants required for agonistic and inverse agonistic ligand properties at the ADP receptor P2Y12. Mol Pharmacol. 2013 Jan;83(1):256-66.  [Content Brief]

  [3]. Gunther LK, et al., Effect of N-Terminal Extension of Cardiac Troponin I on the Ca(2+) Regulation of ATP Binding and ADP Dissociation of Myosin II in Native Cardiac Myofibrils. Biochemistry. 2016 Mar 29;55(12):1887-97.  [Content Brief]