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  5. Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660)

Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660)

Cat. No.: HY-P82915
User Guide for Antibodies Technical Support

Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2660), targeting Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177), with a predicted molecular weight of 116 kDa (observed band size: 105,116,138 kDa). Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660) can be used for WB, IHC-P experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2660), targeting Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177), with a predicted molecular weight of 116 kDa (observed band size: 105,116,138 kDa). Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660) can be used for WB, IHC-P experiment in human, mouse, rat background.
Background

TAOK1 is a serine/threonine-protein kinase involved in multiple biological processes, including the p38/MAPK14 stress-activated MAPK cascade, DNA damage response, and cytoskeleton stability regulation. It activates the p38/MAPK14 cascade by phosphorylating MAP2K3 and MAP2K6, thereby participating in the G2/M checkpoint response to DNA damage. Additionally, TAOK1 phosphorylates Thr-208 of MARK2 to activate its kinase activity, leading to the detachment of MAPT/TAU from microtubules and maintaining cytoskeletal stability. This kinase also regulates apoptotic morphological changes (e.g., cell contraction, membrane blebbing) via the MAPK8/JNK cascade. TAOK1 plays an essential role in neuronal development within the central nervous system (PubMed:33565190) and is implicated in neuronal migration to the cortical plate (by similarity).
Gene ID
SwissProt ID
Synonyms
DPK; JIK; hKFC-A; MAP3K18
Molecular Weight

Predicted band size: 116 kDa; Observed band size: 105,116,138 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Phosphorylated
Research Field

-
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IHC: 1/50-1/100
Application

WB, IHC-P
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser181 of human TAOK1
Database

Entrez Gene: 51347 Human ; 57551 Human ; 9344 Human

SwissProt: Q7L7X3 Human ; Q9H2K8 Human ; Q9UL54 Human

OMIM: 610266 Human

Documentation
User Guide for Antibodies (1077 KB)

Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660)
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