2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Drug Metabolite Potassium Channel
  4. N-Acetylprocainamide hydrochloride

N-Acetylprocainamide hydrochloride  (Synonyms: Acecainide hydrochloride; NAPA hydrochloride)

Cat. No.: HY-101433 Purity: 99.83%
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N-Acetylprocainamide (Acecainide) hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias.

For research use only. We do not sell to patients.

N-Acetylprocainamide hydrochloride

N-Acetylprocainamide hydrochloride Chemical Structure

CAS No. : 34118-92-8

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Based on 1 publication(s) in Google Scholar

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N-Acetylprocainamide hydrochloride Related Antibodies

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1 Publications Citing Use of MCE N-Acetylprocainamide hydrochloride

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Description

N-Acetylprocainamide (Acecainide) hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias[1][2][3].

In Vitro

N-Acetylprocainamide (32-160 nM) hydrochloride decreases the MFF of isolated rabbit right atria in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Acetylprocainamide hydrochloride Related Antibodies
In Vivo

N-Acetylprocainamide (30 mg/kg, i.v., over 15 min) hydrochloride restores sinus rhythm in anesthetized open-chest mongrel dogs with experimental atrial flutter induced by intercaval crush and rapid atrial pacing[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Experimental atrial flutter was induced in 15 anesthetized open-chest mongrel dogs (15-30 kg) by intercaval crush and rapid atrial pacing[3]
Dosage: 30 mg/kg
Administration: i.v., over 15 min
Result: Achieved atrial flutter conversion and atrial flutter reinduction prevention in anesthetized open-chest mongrel dogs.
Achieved significant prolongation of atrial effective refractory period, atrial functional refractory period, atrial flutter cycle length, and corrected QT interval.
Reduced the increment of atrial flutter cycle length in dogs.
Molecular Weight

313.82

Formula

C15H24ClN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCN(CC)CC)C1=CC=C(NC(C)=O)C=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation
References
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N-Acetylprocainamide hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetylprocainamide34118-92-8AcecainideNAPADrug MetabolitePotassium ChannelKcsAInhibitorinhibitorinhibit

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