2. Others Membrane Transporter/Ion Channel
  3. Isotope-Labeled Compounds Potassium Channel
  4. Nicorandil-d4

Nicorandil-d4 (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases.

For research use only. We do not sell to patients.

Nicorandil-d<sub>4</sub> Chemical Structure

Nicorandil-d4 Chemical Structure

CAS No. : 1132681-23-2

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Other Forms of Nicorandil-d4:

Nicorandil-d4 Related Antibodies

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Description

Nicorandil-d4 (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nicorandil-d4 Related Antibodies
Molecular Weight

215.20

Formula

C8H5D4N3O4
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

O=[N+]([O-])OCCNC(C1=C([2H])N=C([2H])C([2H])=C1[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (232.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6468 mL 23.2342 mL 46.4684 mL
5 mM 0.9294 mL 4.6468 mL 9.2937 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.6468 mL 23.2342 mL 46.4684 mL 116.1710 mL
5 mM 0.9294 mL 4.6468 mL 9.2937 mL 23.2342 mL
10 mM 0.4647 mL 2.3234 mL 4.6468 mL 11.6171 mL
15 mM 0.3098 mL 1.5489 mL 3.0979 mL 7.7447 mL
20 mM 0.2323 mL 1.1617 mL 2.3234 mL 5.8086 mL
25 mM 0.1859 mL 0.9294 mL 1.8587 mL 4.6468 mL
30 mM 0.1549 mL 0.7745 mL 1.5489 mL 3.8724 mL
40 mM 0.1162 mL 0.5809 mL 1.1617 mL 2.9043 mL
50 mM 0.0929 mL 0.4647 mL 0.9294 mL 2.3234 mL
60 mM 0.0774 mL 0.3872 mL 0.7745 mL 1.9362 mL
80 mM 0.0581 mL 0.2904 mL 0.5809 mL 1.4521 mL
100 mM 0.0465 mL 0.2323 mL 0.4647 mL 1.1617 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nicorandil-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nicorandil-d41132681-23-2Isotope-Labeled CompoundsPotassium ChannelKcsAInhibitorinhibitorinhibit

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