2. MAPK/ERK Pathway GPCR/G Protein Neuronal Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis
  4. Higenamine (Standard)

Higenamine (Standard)  (Synonyms: Norcoclaurine (Standard); Demethyl-Coclaurine (Standard))

Cat. No.: HY-N2037R
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Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases.

For research use only. We do not sell to patients.

Higenamine (Standard)

Higenamine (Standard) Chemical Structure

CAS No. : 5843-65-2

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Higenamine (Standard) Related Classifications

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Keywords:

Higenamine (Standard)5843-65-2Norcoclaurine (Standard)Demethyl-Coclaurine (Standard)MAP3KMDM-2/p53Adrenergic ReceptorROS KinaseApoptosisMAP kinase kinase kinase, MEKK, MAPKKKBeta Receptorβ2-ARheart failuremyocyteischemia/reperfusionmyocardial infarctionosteoporosisLeukemiaMV4-11MOLM-13strokeCRSC6HNPCsBMSCsInhibitorinhibitorinhibit

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