2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Samidorphan hydrochloride

Samidorphan hydrochloride  (Synonyms: ALKS-33 hydrochloride; RDC-0313 hydrochloride)

Cat. No.: HY-123689A
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Samidorphan hydrochloride is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan hydrochloride acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan hydrochloride primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals.

For research use only. We do not sell to patients.

Samidorphan hydrochloride

Samidorphan hydrochloride Chemical Structure

CAS No. : 2328045-02-7

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Other Forms of Samidorphan hydrochloride:

Samidorphan hydrochloride Related Antibodies

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Description

Samidorphan hydrochloride is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan hydrochloride acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan hydrochloride primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals[1].

In Vivo

Samidorphan (hydrochloride) (10 mg/kg, p.o. for 2 weeks) significantly increases the activity of mice in the stress group[4].
Samidorphan (hydrochloride) (0-10 mg/kg, s.c., 3 h-1 week) can alter the behavior and extracellular neurotransmitter concentration of rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WKY rat[5]
Dosage: 0, 0.3, 1, 3, 10 mg/kg
Administration: Subcutaneous injection (s.c.) for 3 h, 24 h, and 1 week
Result: Had no significant effect at any of the doses or time points tested.
Concurrant administration of BUP (HY-177072) (0.1 mg/kg) significantly reduced immobility at 3h (p<0.01) and this effect persisted up to 1 week.
Abolished this BUPinduced hyperlocomotion.
Significantly reduced the number of marbles buried compared with vehicle-treated rats.
Attenuated BUP-induced changes of extracellular levels of serotonin and dopamine in the medial prefrontal cortex and nucleus accumbens shell.
Animal Model: Swiss mice (180-250 g)[4]
Dosage: 10 mg/kg
Administration: Oral gavage (p.o.) for 2 weeks
Result: Significantly higher (P<0.05) line crossing frequency compared to stressed group in the open field maze.
Significant decrease (P<0.01) in the rearing frequency compared to control group.
Clinical Trial
Molecular Weight

406.90

Formula

C21H27ClN2O4
CAS No.
SMILES

O[C@@]12[C@]3(CC(CC2)=O)C4=C(O)C(C(N)=O)=CC=C4C[C@@]1([H])N(CC3)CC5CC5.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Samidorphan hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Samidorphan2328045-02-7ALKS-33RDC-0313ALKS33ALKS 33RDC0313RDC 0313Opioid ReceptorschizophreniaSAMorally activeInhibitorinhibitorinhibit

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