2. PI3K/Akt/mTOR NF-κB
  3. Akt NF-κB
  4. Phellodendrine

Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendron amurense. phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect .

The free form of the compound does not exist, it is advisable to consider the stable salt form (Phellodendrine chloride) that retains the same biological activity.

For research use only. We do not sell to patients.

Phellodendrine Chemical Structure

Phellodendrine Chemical Structure

CAS No. : 6873-13-8

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Phellodendrine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Phellodendrine

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Description

Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendron amurense. phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect [1].

IC50 & Target[1]

NF-κB

 

Molecular Weight

342.41

Formula

C20H24NO4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=C(OC)C=C2CC[N@@+]3(C)CC4=CC(OC)=C(O)C=C4C[C@@]3([H])C2=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (14.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9205 mL 14.6024 mL 29.2048 mL
5 mM 0.5841 mL 2.9205 mL 5.8410 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9205 mL 14.6024 mL 29.2048 mL 73.0119 mL
5 mM 0.5841 mL 2.9205 mL 5.8410 mL 14.6024 mL
10 mM 0.2920 mL 1.4602 mL 2.9205 mL 7.3012 mL
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Phellodendrine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phellodendrine6873-13-8AktNF-κBPKBProtein kinase BNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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