2. Epigenetics
  3. Histone Demethylase
  4. CBB1007 hydrochloride

CBB1007 hydrochloride is a reversible and selective LSD1 inhibitor with an IC50 of 5.27 µM for human LSD1. CBB1007 hydrochloride significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me. CBB1007 hydrochloride shows selectivity for LSD1 over LSD2 or JARID1A, and induces differentiation-related genes in pluripotent cells. CBB1007 hydrochloride is studied in  non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma.

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CBB1007 hydrochloride

CBB1007 hydrochloride Chemical Structure

CAS No. : 2070014-96-7

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CBB1007 hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CBB1007 hydrochloride

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    CBB1007 hydrochloride purchased from MedChemExpress. Usage Cited in: BMC Neurosci. 2022 Nov 10;23(1):63.  [Abstract]

    CBB1007 (CBB) elevates H3K4me2 expression in RGC-5 cells, after which miR-21-5p expression levels are increased .

    View All Histone Demethylase Isoform Specific Products:

    View All Isoforms
    KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    CBB1007 hydrochloride is a reversible and selective LSD1 inhibitor with an IC50 of 5.27 µM for human LSD1. CBB1007 hydrochloride significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me. CBB1007 hydrochloride shows selectivity for LSD1 over LSD2 or JARID1A, and induces differentiation-related genes in pluripotent cells. CBB1007 hydrochloride is studied in  non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma[1][2].

    IC50 & Target[2]

    KDM1/LSD1

    5.27 μM (IC50)

    In Vitro

    CBB1007 (0-100 μM; 30 h; F9) hydrochloride inhibits F9 cell growth[2].
    CBB1007 (5-20 μM; 14 days; hESCs) hydrochloride increases lipid droplet formation in hESCs during adipogenesis[1].
    CBB1007 (5-20 μM; 14 days; hESCs) hydrochloride reduces LSD1 and histone H3 levels while increasing H3K4me2 in human embryonic stem cells (hESCs)[1].
    CBB1007 (5-20 μM; 14 days; hESCs) hydrochloride upregulates adipocyte marker genes PPARγ-2 and C/EBPα in hESCs[1].
    CBB1007 (0.5-20 μM; 24 h; F9) hydrochloride activates the expression of CHRM4 and SCN3A genes[2].
    CBB1007 (10 μM) hydrochloride significantly blocks the demethylase activity of LSD1 on mono- and di-methylated H3K4, but not tri-methylated H3K4 or di-methylated H3K9[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    CBB1007 hydrochloride Related Antibodies

    Cell Proliferation Assay[2]

    Cell Line: F9 cell
    Concentration: 1 μM, 5 μM, 10 μM, 50 μM, 100 μM
    Incubation Time: 30 h
    Result: Cell growth was significantly inhibited.

    Cell Differentiation Assay[1]

    Cell Line: hESCs
    Concentration: 5 μM, 10 μM, 20 μM
    Incubation Time: 14 days
    Result: Lipid droplet density increased, and droplets fused due to high density.

    Western Blot Analysis[1]

    Cell Line: hESCs
    Concentration: 5 μM, 10 μM, 20 μM
    Incubation Time: 14 days
    Result: LSD1 and histone H3 expression decreased, while H3K4me2 levels increased with higher doses.

    Real Time qPCR[1]

    Cell Line: hESCs
    Concentration: 5 μM, 10 μM, 20 μM
    Incubation Time: 14 days
    Result: PPARγ-2 and C/EBPα expression increased with increasing doses.

    Real Time qPCR[2]

    Cell Line: F9
    Concentration: 0.5 μM, 1 μM, 5 μM, 20 μM
    Incubation Time: 24 h
    Result: The expression of CHRM4 and SCN3A genes were activated. And markedly induced the expression of genes for differentiation, such as FOXA2.
    Molecular Weight

    716.91

    Formula

    C27H39Cl5N8O4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl.NC(N1CCN(CC1)CC2=CC(C(OC)=O)=CC(C(N3CCN(CC3)C(C4=CC=C(C=C4)C(N)=N)=O)=O)=C2)=N
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Purity & Documentation
    References
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    CBB1007 hydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CBB10072070014-96-7CBB 1007CBB-1007Histone DemethylaseAdipogenesisLSD1 protein levelhESCsovarian tumorsembryonic stem cellsFIGO stageLSD1 mRNA overexpressionseminomaovarian cancer cell linesH3K4 methylationHistone modificationtranscriptomic signaturecytotoxicitycancer-selectiveLSD1 inhibitorsteratocarcinomaMTS/PMS assayLSD1Sox2embryonic carcinomaRNA interferenceepigenetic targetschemical inhibitionpluripotent cancer cellsOct4histone demethylaseInhibitorinhibitorinhibit

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