2. Epigenetics
  3. Histone Demethylase
  4. GSK-J4 hydrochloride (Standard)

GSK-J4 hydrochloride (Standard) 

Cat. No.: HY-15648FR Purity: ≥98%
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GSK-J4 (hydrochloride) (Standard) is the analytical standard of GSK-J4 (hydrochloride). This product is intended for research and analytical applications. GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1.

For research use only. We do not sell to patients.

GSK-J4 hydrochloride (Standard) Chemical Structure

GSK-J4 hydrochloride (Standard) Chemical Structure

CAS No. : 1797983-09-5

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Description
Molecular Weight

453.96

Formula

C24H28ClN5O2
CAS No.
SMILES

O=C(OCC)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1.Cl
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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GSK-J4 hydrochloride (Standard) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-J4 hydrochloride (Standard)1797983-09-5Histone DemethylaseH3K27me3/me2inflammationdendriticcellsTGF-βdiabeticmiceTh1Th17demethylaseInhibitorinhibitorinhibit

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