CCR4 Protein-VLP, Human (HEK293)

CCR4 protein-VLP is a multifunctional entity that acts as a high-affinity receptor for CC-type chemokines and specifically binds CCL17/TARC, CCL22/MDC, and CKLF1. It mediates chemotactic responses through G(i) protein and activates the phosphatidylinositol-calcium second messenger system. CCR4 Protein-VLP, Human (HEK293) is the recombinant human-derived CCR4 protein, expressed by HEK293, with tag free.Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening. Given the high immunogenicity of VLPs, the immunization protocol such as antigen dose, schedule, and adjuvant, requires optimization. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

CCR4 Protein-VLP, a versatile entity, stands out as a high-affinity receptor for C-C type chemokines, specifically demonstrating binding affinity for CCL17/TARC, CCL22/MDC, and CKLF isoform 1/CKLF1. Its functional spectrum extends to the mediation of chemotactic responses through G(i) proteins, which activate a phosphatidylinositol-calcium second messenger system. Beyond its role as a chemoattractant homing receptor on circulating memory lymphocytes, CCR4 Protein-VLP also serves as a coreceptor for certain primary HIV-2 isolates. In the central nervous system (CNS), intriguingly, it has the potential to mediate hippocampal-neuron survival, adding a layer of complexity to its multifaceted functions.

Human

HEK293

Tag Free

P51679 (M1-L360)

1233

Full Length

Solution.

Supplied as 0.2 μm filtered solution of PBS, Arginine, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.