2. Membrane Transporter/Ion Channel Cell Cycle/DNA Damage
  3. ATP Synthase DNA/RNA Synthesis
  4. KI-DX-014

KI-DX-014 is a DDX21 inhibitor with an IC50 of 3.31  μM. KI-DX-014 significantly inhibits the DDX21-RNA interaction and modulates ATPase activity and biomolecular condensate formation. KI-DX-014 reduces the DDX21-dependent release of P-TEFb from the 7SK snRNP complex, inhibits P-TEFb-dependent phosphorylation of the RNA polymerase II CTD, and induces developmental defects in zebrafish embryos. KI-DX-014 can be used for cancers and neurodegenerative disorders research.

For research use only. We do not sell to patients.

KI-DX-014

KI-DX-014 Chemical Structure

CAS No. : 1309288-83-2

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Description

KI-DX-014 is a DDX21 inhibitor with an IC50 of 3.31  μM. KI-DX-014 significantly inhibits the DDX21-RNA interaction and modulates ATPase activity and biomolecular condensate formation. KI-DX-014 reduces the DDX21-dependent release of P-TEFb from the 7SK snRNP complex, inhibits P-TEFb-dependent phosphorylation of the RNA polymerase II CTD, and induces developmental defects in zebrafish embryos. KI-DX-014 can be used for cancers and neurodegenerative disorders research[1].

Molecular Weight

330.38

Formula

C17H22N4O3
CAS No.
SMILES

COC1=CC=C(C=C1)N2N=CC(CN3CCC(C(O)=O)(C3)N)=C2C
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Purity & Documentation
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KI-DX-014 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KI-DX-0141309288-83-2ATP SynthaseDNA/RNA SynthesisInhibitorDDX21-RNA interactionATPaseBiomolecular condensateP-TEFbII CTDZebrafish embryos CancersNeurodegenerative disordersinhibitorinhibit

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