2. Protein Tyrosine Kinase/RTK Apoptosis MAPK/ERK Pathway GPCR/G Protein PI3K/Akt/mTOR JAK/STAT Signaling Epigenetics Stem Cell/Wnt
  3. FLT3 Apoptosis Ras p38 MAPK PI3K Akt JAK STAT
  4. Clifutinib

Clifutinib (Compound 9e) is an orally active and selective internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) inhibitor with an IC50 value of 15.1 nM. Clifutinib inhibits the activity of FLT3-ITD kinase and blocks the downstream RAS/MAPK, PI3K/AKT, and JAK/STAT5 signaling pathways of FLT3. Clifutinib induces apoptosis of acute myeloid leukemia (AML) cells with FLT3-ITD mutations. Clifutinib is promising for research of relapsed/refractory FLT3-ITD-positive acute myeloid leukemia.

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Clifutinib Chemical Structure

Clifutinib Chemical Structure

CAS No. : 1862226-99-0

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Clifutinib Related Antibodies

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K-Ras H-Ras N-Ras Ras

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

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JAK1 JAK2 JAK3 Tyk2 JAK

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STAT3 STAT5 STAT6 STAT1

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Description

Clifutinib (Compound 9e) is an orally active and selective internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) inhibitor with an IC50 value of 15.1 nM. Clifutinib inhibits the activity of FLT3-ITD kinase and blocks the downstream RAS/MAPK, PI3K/AKT, and JAK/STAT5 signaling pathways of FLT3. Clifutinib induces apoptosis of acute myeloid leukemia (AML) cells with FLT3-ITD mutations. Clifutinib is promising for research of relapsed/refractory FLT3-ITD-positive acute myeloid leukemia[1].

Molecular Weight

502.60

Formula

C29H34N4O4
CAS No.
SMILES

O=C(NC1=NOC(C(C)(C)C)=C1)NC2=CC=C(C#CC3=CC=C(OCCCN4CCOCC4)C=C3)C=C2
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Clifutinib Related Classifications

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Keywords:

Clifutinib1862226-99-0FLT3ApoptosisRasp38 MAPKPI3KAktJAKSTATCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Phosphoinositide 3-kinasePKBProtein kinase BJanus kinaseorally activeFLT3-ITDRAS/MAPKacute myeloid leukemiaInhibitorinhibitorinhibit

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