2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. GSK4418959

GSK4418959  (Synonyms: IDE275)

Cat. No.: HY-169422 Purity: 98.72% ee.: 96.40%
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GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer.

For research use only. We do not sell to patients.

GSK4418959

GSK4418959 Chemical Structure

CAS No. : 3064599-36-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
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Based on 1 publication(s) in Google Scholar

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Description

GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer[1].

Clinical Trial
Molecular Weight

646.65

Formula

C31H30F4N4O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(C(F)(F)F)C=C1F)[C@@H]2CCC[C@H](C3=CC=C(N(C)S(=O)(C4=CC(N=C(C)N5C)=C5C=C4)=O)C=C3)[C@H]2C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (154.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5464 mL 7.7322 mL 15.4643 mL
5 mM 0.3093 mL 1.5464 mL 3.0929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5464 mL 7.7322 mL 15.4643 mL 38.6608 mL
5 mM 0.3093 mL 1.5464 mL 3.0929 mL 7.7322 mL
10 mM 0.1546 mL 0.7732 mL 1.5464 mL 3.8661 mL
15 mM 0.1031 mL 0.5155 mL 1.0310 mL 2.5774 mL
20 mM 0.0773 mL 0.3866 mL 0.7732 mL 1.9330 mL
25 mM 0.0619 mL 0.3093 mL 0.6186 mL 1.5464 mL
30 mM 0.0515 mL 0.2577 mL 0.5155 mL 1.2887 mL
40 mM 0.0387 mL 0.1933 mL 0.3866 mL 0.9665 mL
50 mM 0.0309 mL 0.1546 mL 0.3093 mL 0.7732 mL
60 mM 0.0258 mL 0.1289 mL 0.2577 mL 0.6443 mL
80 mM 0.0193 mL 0.0967 mL 0.1933 mL 0.4833 mL
100 mM 0.0155 mL 0.0773 mL 0.1546 mL 0.3866 mL
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GSK4418959 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK44189593064599-36-3IDE275GSK 4418959GSK-4418959IDE 275IDE-275DNA/RNA SynthesisWRN helicasenon-covalentreversibleselectivemicrosatellite instability-high (MSI-H) cancerInhibitorinhibitorinhibit

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