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  4. BRD-K98645985

BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 μM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity.

For research use only. We do not sell to patients.

BRD-K98645985 Chemical Structure

BRD-K98645985 Chemical Structure

CAS No. : 1357647-78-9

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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 2 publication(s) in Google Scholar

BRD-K98645985 Related Antibodies

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Description

BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 μM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity[1].

IC50 & Target[1]

BAF transcriptional repression

2.37 μM (EC50)

HIV-1

 

In Vitro

BRD-K98645985 (30 μM; 18 hours) treatment shows a 5-fold increase in Bmi1, 2.6-fold increase in Ring1, and 3.3-fold decrease in Fgf4[1].
BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BRD-K98645985 Related Antibodies
Molecular Weight

573.73

Formula

C33H43N5O4
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O=C(NC1=CC=C(OC[C@H](C)N(CC2=CC=C(C3=NC=CC=C3)C=C2)C[C@H](C)[C@@H](OC)CN(C)C4=O)C4=C1)NC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.67%

SDS (251 KB)

COA (259 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References
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BRD-K98645985 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD-K986459851357647-78-9HIVHuman immunodeficiency virusBAFARID1Anon-toxic12-memberedmacrolactamlatencyreversalGFPT-cellsviralInhibitorinhibitorinhibit

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