2. GPCR/G Protein MAPK/ERK Pathway PI3K/Akt/mTOR
  3. Ras PI3K
  4. VVD-849

VVD-849 is a RAS ligand. VVD-849 binds covalently to cysteine 242 in the RAS binding domain of PI3K p110α and promotes RAS/PI3K interaction. VVD-849 partially inhibits pAKT(S473) in HER2 over-expressing tumors. VVD-849 can be used cancers like breast cancer research.

For research use only. We do not sell to patients.

VVD-849

VVD-849 Chemical Structure

CAS No. : 3055321-14-4

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VVD-849 Related Antibodies

Top Publications Citing Use of Products

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K-Ras H-Ras N-Ras Ras

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

VVD-849 is a RAS ligand. VVD-849 binds covalently to cysteine 242 in the RAS binding domain of PI3K p110α and promotes RAS/PI3K interaction. VVD-849 partially inhibits pAKT(S473) in HER2 over-expressing tumors. VVD-849 can be used cancers like breast cancer research[1].

Molecular Weight

636.15

Formula

C29H31ClFN3O6S2
CAS No.
SMILES

ClC1=CC(C2=CC(OCC3=NC=CC=C3)=CC=C2)=C(S(N4CCC(C(N[C@@H](C)/C=C\S(C)(=O)=O)=O)(F)CC4)(=O)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VVD-849 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VVD-8493055321-14-4VVD849VVD 849RasPI3KPhosphoinositide 3-kinaseLigandRASCysteine 242RAS/PI3K interactionHEK293T cellsBreast cancerInhibitorinhibitorinhibit

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