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Pathways Recommended: PI3K/Akt/mTOR
Results for "

Na( )-K( )-Cl( )

" in MedChemExpress (MCE) Product Catalog:

3308

Inhibitors & Agonists

25

Screening Libraries

51

Fluorescent Dye

54

Biochemical Assay Reagents

246

Peptides

3

MCE Kits

35

Inhibitory Antibodies

480

Natural
Products

395

Recombinant Proteins

169

Isotope-Labeled Compounds

187

Antibodies

14

Click Chemistry

184

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2660
    Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide

    GD4K-na

    		 Enteropeptidase Others
    Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide (GD4K-na) is a substrate for human enteropeptidase (Km: 0.16 mM) .
    Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide
  • HY-155482
    NA-184

    		Proteasome Neurological Disease
    NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC50 of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI) .
    NA-184
  • HY-137004
    Indazole-Cl

    Ind-Cl

    		 Estrogen Receptor/ERR COX Inflammation/Immunology
    Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs) .
    Indazole-Cl
  • HY-162455
    NA-014

    		EAAT Others
    NA-014 (40) is a selective EAAT2 positive allosteric modulator (PAM), with an EC50 of 3 nM .
    NA-014
  • HY-RS08065
    MAP3K7CL Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MAP3K7CL Human Pre-designed siRNA Set A contains three designed siRNAs for MAP3K7CL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MAP3K7CL Human Pre-designed siRNA Set A
    MAP3K7CL Human Pre-designed siRNA Set A
  • HY-129622
    NH2-PEG5-C6-Cl

    		PROTAC Linkers Cancer
    NH2-PEG5-C6-Cl (K-7) is a linker which refers to the PEG composition. NH2-PEG5-C6-Cl can be used in the synthesis of a series of compounds that induce degradation of intracellular molecules by autophagy .
    NH2-PEG5-C6-Cl
  • HY-144063
    INSCoV-600K(1)

    		SARS-CoV Infection
    INSCoV-600K(1) is a potent inhibitor of M pro (3CL pro). Proteases (PL pro and 3CL pro) are involved with transcription and replication of the virus. INSCoV-600K(1) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1) .
    INSCoV-600K(1)
  • HY-169688
    NA-17

    		MDM-2/p53 Apoptosis Cancer
    NA-17 is a naphthalimide compound with anti-tumor activity and lower toxicity to normal cells like HL-7702 and WI-38. NA-17 exhibits a p53-dependent selective inhibition in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of NSCLC cells. NA-17 can cause cell cycle arrest in the G1 phase, leading to apoptosis and cell death .
    NA-17
  • HY-N10627
    NA2 Glycan

    		Endogenous Metabolite Others
    NA2 Glycan is NA2 N-linked oligosaccharide. NA2 is the asialo-substructure of A2 glycan. NA2 glycan can be isolated from mammalian serum glycoproteins, such as serum IgG .
    NA2 Glycan
  • HY-129213
    CL-242817

    		Angiotensin-converting Enzyme (ACE) Cardiovascular Disease Others
    CL-242817 is an orally available angiotensin converting enzyme (ACE) inhibitor. CL-242817 inhibits the conversion of angiotensin I to angiotensin II and has blood pressure lowering activity. CL-242817 can also improve Monocrotaline (HY-N0750) induced lung injury. CL-242817 can be used in the study of pulmonary fibrosis and hypertension-related diseases .
    CL-242817
  • HY-103505
    CL 218872

    		GABA Receptor Neurological Disease
    CL 218872 is an orally active and selective ligand for the benzodiazepine receptor subtype BZ1. CL 218872 exhibits anxiolytic, sedative and anticonvulsant activities. CL 218872 can be used in researches of anxiety related disorders and epilepsy .
    CL 218872
  • HY-19126
    CL-184005

    		Platelet-activating Factor Receptor (PAFR) Infection Cardiovascular Disease
    CL-184005 is an antagonist for platelet-activating factor (PAF), that inhibits the PAF-induced platelet aggregation with IC50 of 600 nM and 510 nM, in human and rabbit platelet-rich plasma. CL-184005 protects the rats from endotoxin-induced gastrointestinal damage and hypotension. CL-184005 exhibits potential attenuating Gram-negative bacterial sepsis .
    CL-184005
  • HY-117858
    CL-329167

    		Angiotensin Receptor Cardiovascular Disease
    CL-329167 (compound 12) is an orally active and competitive angiotensin II receptor antagonist (IC50=6 nM). CL-329167 can be used in the research of hypertension .
    CL-329167
  • HY-100359
    CL-82198
    5+ Cited Publications

    		 MMP Inflammation/Immunology Cancer
    CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs . CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression .
    CL-82198
  • HY-126038
    BTS 39542

    		Chloride Channel Potassium Channel Sodium Channel Cardiovascular Disease
    BTS 39542 is an orally active inhibitor for Na+ K+ Cl cotransport system, that exhibits diuretic activity, and can be used in hypertension and edema research .
    BTS 39542
  • HY-169829
    CL-424032

    		Sodium Channel Others
    CL-424032 is a sodium channel inhibitor .
    CL-424032
  • HY-116771A
    CL 316243
    10+ Cited Publications

    		 Adrenergic Receptor Metabolic Disease
    CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors [1].CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate . CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence .
    CL 316243
  • HY-120450
    CL-55

    		Bacterial Infection Inflammation/Immunology
    CL-55 is an inhibitor for type three secretion system of Chlamydia trachomatis, that blocks the effector molecules delivery of bacteria into host cells. CL-55 ameliorates the C. trachomatis infection and inflammation in mice .
    CL-55
  • HY-148191
    CL-197

    		HIV Protease Infection Cardiovascular Disease Inflammation/Immunology Cancer
    CL-197 is an orally active and long-acting purine anti-HIV nucleoside reverse transcriptase inhibitor (NRTI). CL-197 has potential effect on the research of viral, oncological and cerebrovascular diseases . CL-197 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    CL-197
  • HY-130178
    CL-385319

    		Endogenous Metabolite Infection
    CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection. CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319 .
    CL-385319
  • HY-110046
    CL-82198 hydrochloride

    		MMP Others
    CL-82198 hydrochloride is a selective inhibitor of MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP-9, and TACE .
    CL-82198 hydrochloride
  • HY-19146
    CL-275838

    		Others Neurological Disease
    CL-275838 is a memory-enhancing agent, also with potent antidepressant activities.
    CL-275838
  • HY-116662
    CL 232468

    		Others Inflammation/Immunology
    CL 232468 is an immunosuppressive agent .
    CL 232468
  • HY-P5994
    MeOSuc-AAPF-CMK

    MeOSuc-Ala-Ala-Pro-Phe-CH₂Cl

    		 Ser/Thr Protease Others
    MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH Cl) is a potent proteinase K inhibitor .
    MeOSuc-AAPF-CMK
  • HY-161397
    NA-1-157

    		Bacterial Infection Inflammation/Immunology
    NA-1-157 is a potent irreversible covalent inhibitor of the GES-5 carbapenemase, with a MIC of 0.5 μg/mL .
    NA-1-157
  • HY-W074975R
    CL 5343 (Standard)

    		Carbonic Anhydrase Cancer
    CL 5343 (Standard) is the analytical standard of CL 5343. This product is intended for research and analytical applications. CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is an inhibitor of human carbonic anhydrase B (HCA-B). CL 5343 can serve as a CA9 ligand to achieve the targeted delivery of maytansinoid to the cell membrane of SKRC52 renal cancer cells .
    CL 5343 (Standard)
  • HY-168301
    CL-13

    		Cholinesterase (ChE) Amyloid-β Neurological Disease
    CL-13 is a butyrylcholinesterase (BChE) inhibitor, with an IC50 of 1.15 μM, and a selectivity index (SI) of 9.2 for acetylcholinesterase. CL-13 shows antioxidant activity in SH-SY5Y cells (DPPH EC50 = 47.01 μM) and has the ability to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at 50 μM. CL-13 can reverse cognitive impairment caused by scopolamine (HY-N0296) without affecting the mice's motor skills .
    CL-13
  • HY-117479
    CL67

    		HIF/HIF Prolyl-Hydroxylase Cancer
    CL67 is a potent hypoxia-inducible factor (HIF) pathway inhibitor. CL67 interferes G-quadruplex structures within promoter sequences. CL67 can be used in research of renal cancer .
    CL67
  • HY-P1347
    RETF-4NA

    		Biochemical Assay Reagents Metabolic Disease
    RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α2M .
    RETF-4NA
  • HY-128947
    CL2 Linker

    		ADC Linker Cancer
    CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours) .
    CL2 Linker
  • HY-W454632
    Thalidomide-5-Cl

    		Ligands for E3 Ligase Cancer
    Thalidomide-5-Cl is a Thalidomide analog that can be useful in PROTAC research.
    Thalidomide-5-Cl
  • HY-139547
    Thalidomide-5,6-Cl

    		Ligands for E3 Ligase Autophagy Apoptosis Cancer
    Thalidomide-5,6-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-Cl can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-5,6-Cl
  • HY-116771
    CL 316243 free acid
    10+ Cited Publications

    		 Adrenergic Receptor Metabolic Disease
    CL316243 free acid is a highly potent selective β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors. CL316243 free acid is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 free acid has the potential for the treatment obesity, diabetes and urge urinary incontinence .
    CL 316243 free acid
  • HY-162944
    NA-Ir

    		Ferroptosis Mitochondrial Metabolism STING Autophagy Cancer
    NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H2S levels .
    NA-Ir
  • HY-W096116
    PEG2-Cl

    		PROTAC Linkers Cancer
    PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    PEG2-Cl
  • HY-103229
    Cl-HIBO

    		iGluR Neurological Disease
    Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties .
    Cl-HIBO
  • HY-10508
    (R)-PD 0325901CL

    		MEK Cancer
    (R)-PD 0325901CL is an isomer of PD 0325901CL. PD 0325901CL is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) involved in cancer research. PD 0325901CL inhibits the growth of cancer cells in vitro and in vivo .
    (R)-PD 0325901CL
  • HY-134406
    6-Cl-cPuMP sodium

    		Phosphodiesterase (PDE) Neurological Disease
    6-Cl-cPuMP (sodium) is a cAMP analog with active chlorine function. 6-Cl-cPuMP (sodium) has good membrane permeability and phosphodiesterase (PDE) stability. 6-Cl-cPuMP (sodium) can be used for nervous system research .
    6-Cl-cPuMP sodium
  • HY-126350
    CL2-SN-38

    		Drug-Linker Conjugates for ADC Cancer
    CL2-SN-38 is a cleavable linker-based agent-Linker conjugate, it can conjugate with the anti-Trop-2-humanized antibody hRS7. CL2-SN-38 can be used for the reasearch of cancer .
    CL2-SN-38
  • HY-100574D
    D-Cl-amidine hydrochloride

    		Protein Arginine Deiminase Apoptosis Cancer
    D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity .
    D-Cl-amidine hydrochloride
  • HY-100574C
    D-Cl-amidine

    		Protein Arginine Deiminase Apoptosis Inflammation/Immunology Cancer
    D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity .
    D-Cl-amidine
  • HY-W391701
    Pomalidomide-COCH2Cl

    		Ligands for E3 Ligase Cancer
    Pomalidomide-COCH2Cl is a derivative of Pomalidomide with an chloroacetamide group on the benzyl ring.
    Pomalidomide-COCH2Cl
  • HY-102076
    0990CL

    		Adrenergic Receptor Others
    0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP .
    0990CL
  • HY-149594
    CL-Pa

    		Pantetheinase Metabolic Disease
    CL-Pa is a chemiluminescent probe suitable for detection of urinary Vanin-1. CL-Pa can be used to detect drug-induced acute kidney injury (AKI) through urinalysis .
    CL-Pa
  • HY-B1039
    Ambroxol
    2 Publications Verification

    NA-872

    		 Glycosidase Autophagy Neurological Disease Metabolic Disease
    Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .
    Ambroxol
  • HY-B1039A
    Ambroxol hydrochloride
    2 Publications Verification

    NA-872 hydrochloride

    		 Glycosidase Autophagy Neurological Disease Metabolic Disease
    Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .
    Ambroxol hydrochloride
  • HY-128946
    CL2A-SN-38
    2 Publications Verification

    		 Drug-Linker Conjugates for ADC Inflammation/Immunology Cancer
    CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects .
    CL2A-SN-38
  • HY-157252
    CL4F8-6

    		Liposome Cancer
    CL4F8-6 is an ionizable cationic lipid with a pKa of 6.14. CL4F8-6 can be used in lipid nanoparticles (LNPs)-based mRNA therapeutics .
    CL4F8-6
  • HY-122217
    Pyridate

    CL 11344

    		 Herbicide Others
    Pyridate (CL 11344) is a herbicide, which is used in the agricultural management of cereals, maize and rape .
    Pyridate
  • HY-170868
    CL2A-FL118

    		Drug-Linker Conjugates for ADC Cancer
    CL2A-FL118 is a drug-linker for synthesis of ADC molecule Sac-CL2A-FL118 .
    CL2A-FL118

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