2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. CL5D

CL5D is an activator of protein deacetylase SIRT6. CL5D can significantly enhance the deacetylation activity of SIRT6 and improve its catalytic efficiency. CL5D regulates SIRT6 activity by promoting conformational changes, especially dependent on the role of Arg-65 residue. CL5D can be used to study the activation mechanism of SIRT6 and its function in metabolism, DNA repair and aging.

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CL5D Chemical Structure

CL5D Chemical Structure

CAS No. : 2488745-53-3

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CL5D Related Antibodies

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Description

CL5D is an activator of protein deacetylase SIRT6. CL5D can significantly enhance the deacetylation activity of SIRT6 and improve its catalytic efficiency. CL5D regulates SIRT6 activity by promoting conformational changes, especially dependent on the role of Arg-65 residue. CL5D can be used to study the activation mechanism of SIRT6 and its function in metabolism, DNA repair and aging[1].

Molecular Weight

731.58

Formula

C29H11Cl7N2O6
CAS No.
SMILES

O=C(C1=CC=C2C(N(C3=CC=C(N(C(C4=C(Cl)C=C(Cl)C=C4Cl)=O)C(C5=C(Cl)C=C(Cl)C=C5Cl)=O)C(Cl)=C3)C(C2=C1)=O)=O)O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CL5D Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL5D2488745-53-3SirtuinSIRT6HEK293T cellsArg-65HDACInhibitorinhibitorinhibit

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