ATIC Antibody (YA5245)

ATIC Antibody (YA5245) is a mouse-derived and non-conjugated monoclonal antibody, targeting to ATIC. It can be applicated for WB assays, in the background of human, mouse, rat.

ATIC is a bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. It acts as a transformylase, incorporating a formyl group into the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR), utilizing either 10-formyldihydrofolate or 10-formyltetrahydrofolate as the formyl donor. Additionally, ATIC catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). It can also convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in leukemia treatment. Furthermore, ATIC promotes insulin receptor (INSR) autophosphorylation and is involved in INSR internalization.

P31939

Observed band size: 64 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:1000

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human ATIC protein fragments expressed in E.coli.