CP 339818 hydrochloride

Name: CP 339818 hydrochloride
Brand: MedChemExpress
SKU: HY-108574
Rating: 4.5 (1 reviews)

Cat. No.: HY-108574 Purity: 99.61%: Data Sheet
COA

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Handling Instructions
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CP 339818 hydrochloride is a non-peptide Kv1.3 channel (IC₅₀ = 200 nM) and Kv1.4 channel blocker. CP 339818 hydrochloride inhibits HCN channel with IC₅₀s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl^-). CP 339818 hydrochloride has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP 339818 hydrochloride selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP 339818 hydrochloride can be used to study the physiological functions of HCN and Kv channels.

For research use only. We do not sell to patients.

CP 339818 hydrochloride Chemical Structure

CAS No. : 478341-55-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

Kv1.3

200 nM (IC₅₀)

Kv1.4

In Vitro

CP 339818 hydrochloride suppresses human T cell activation, suggesting that blockade of Kv1.3 alone is sufficient to inhibit this process^[1].
CP 339818 (5 μM) hydrochloride effectively block the remaining outward potassium current in Kv2.1^⁻/⁻ β cells, and does not significantly enhance glucose-stimulated insulin secretion (GSIS)^[2].
CP 339818 (0-100 μM) hydrochloride's inhibitory effect on HCN1 and HCN4 in low-concentration of Cl^- internal solution is weakened with IC₅₀ of 26.2 and > 100 μM, , and this blocking effect is also voltage-dependent (the higher the voltage, the stronger the blocking effect)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

340.89

Formula

C₂₁H₂₅ClN₂

CAS No.

478341-55-8

Appearance

Solid

Color

White to off-white

SMILES

CCCCC/N=C1C=CN(CC2=CC=CC=C2)C3=C\1C=CC=C3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (183.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9335 mL	14.6675 mL	29.3350 mL
5 mM	0.5867 mL	2.9335 mL	5.8670 mL
10 mM	0.2933 mL	1.4667 mL	2.9335 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Purity & Documentation

Purity: 99.61%

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Data Sheet (271 KB) SDS (393 KB)

COA (245 KB) HNMR (141 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. A Nguyen, et al. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol. 1996 Dec;50(6):1672-9. [Content Brief]

[2]. Jacobson DA, et al. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J Physiol. 2010 Sep 15;588(Pt 18):3525-37. [Content Brief]

[3]. Lee YT, et al. Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay. Eur J Pharmacol. 2008 Feb 26;581(1-2):97-104. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9335 mL	14.6675 mL	29.3350 mL	73.3374 mL
	5 mM	0.5867 mL	2.9335 mL	5.8670 mL	14.6675 mL
	10 mM	0.2933 mL	1.4667 mL	2.9335 mL	7.3337 mL
	15 mM	0.1956 mL	0.9778 mL	1.9557 mL	4.8892 mL
	20 mM	0.1467 mL	0.7334 mL	1.4667 mL	3.6669 mL
	25 mM	0.1173 mL	0.5867 mL	1.1734 mL	2.9335 mL
	30 mM	0.0978 mL	0.4889 mL	0.9778 mL	2.4446 mL
	40 mM	0.0733 mL	0.3667 mL	0.7334 mL	1.8334 mL
	50 mM	0.0587 mL	0.2933 mL	0.5867 mL	1.4667 mL
	60 mM	0.0489 mL	0.2445 mL	0.4889 mL	1.2223 mL
	80 mM	0.0367 mL	0.1833 mL	0.3667 mL	0.9167 mL
	100 mM	0.0293 mL	0.1467 mL	0.2933 mL	0.7334 mL